CAJ | 학술논문

目的：观察急性脑梗死早期使用氯吡格雷联合阿司匹林用药方法、疗效。方法103例急性脑梗死患者随机分为三组，对照组予阿司匹林口服治疗，治疗组1予氯吡格雷联合阿司匹林口服治疗，治疗组2一经确诊即予氯吡格雷联合阿司匹林嚼服治疗，三组疗程均为14 d。观察三组治疗前后NIHSS总评分比较及疗效总有效率比较。结果治疗后NIHSS评分均有不同程度的改善，治疗组1治疗效果显著优于对照组，治疗组2治疗效果显著优于治疗组1(P<0．05)；临床总有效率各组差异亦有统计学意义(P<0．05)。结论氯吡格雷联合阿司匹林治疗急性脑梗死疗效优于单用阿司匹林，而确诊后立即嚼服作用优于常规口服，急性脑梗死早期尽早发挥双抗治疗的作用会使患者获得更大的受益。
목적：관찰급성뇌경사조기사용록필격뢰연합아사필림용약방법、료효。방법103례급성뇌경사환자수궤분위삼조，대조조여아사필림구복치료，치료조1여록필격뢰연합아사필림구복치료，치료조2일경학진즉여록필격뢰연합아사필림작복치료，삼조료정균위14 d。관찰삼조치료전후NIHSS총평분비교급료효총유효솔비교。결과치료후NIHSS평분균유불동정도적개선，치료조1치료효과현저우우대조조，치료조2치료효과현저우우치료조1(P<0．05)；림상총유효솔각조차이역유통계학의의(P<0．05)。결론록필격뢰연합아사필림치료급성뇌경사료효우우단용아사필림，이학진후립즉작복작용우우상규구복，급성뇌경사조기진조발휘쌍항치료적작용회사환자획득경대적수익。
Objective Medication methods and efficacy of early use of Clopidogrel Hydrogen Sulfate Tablets in combination with aspirin in acute cerebral infarction. Methods 113 patients with acute cerebral infarction were randomly divided into three groups, the control group were given aspirin oral treatment, the first treatment group were given oral clopidogrel in combination with aspirin therapy, the second treatment group once confirmed chew clopidogrel in combination with aspirin immediately. The course of treatment was 14 days. Observed total NIHSS score comparison and efficacy of 3 groups before and after treatment the total effective rate. Results After treatment NIHSS score improved in varying degrees, a therapeutic effect of the first treatment group was significantly better than the control group, the second treatment was significantly better than the first treatment group (P<0.05);clinical total efficiency of the group differences also was statistically significant (P<0.05).Conclusion Clopidogrel in combination with aspirin treatment of acute cerebral infarction more effective than aspirin alone, immediately after diagnosis chew superior to conventional oral . acute cerebral infarction as early as possible to play a double-antibody treatment patients will get greater benefit. If the early use of clopidogrel in combination with aspirin in acute cerebral infarction, then the treatment would be better.