当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2014年
2期
72-73
,共2页
精神分裂症%抗精神病药物%腹部彩色多普勒超声
精神分裂癥%抗精神病藥物%腹部綵色多普勒超聲
정신분렬증%항정신병약물%복부채색다보륵초성
Schizophrenia%Antipsychotics%Abdominal ultrasound
目的：探讨长期应用抗精神病药物的精神分裂症患者腹腔脏器异常改变情况。方法对2011年6月-2013年8月在本院各个病区住院的200精神分裂症患者（观察组）进行腹部彩色多普勒超声检查，并与200例健康体检者(对照组)进行对比分析。比较两组研究对象腹部彩色多普勒超声检查阳性率，并比较不同年龄、不同用药时间、不同用药方式及不同性别精神分裂症患者腹部彩色多普勒超声检查阳性率。结果观察组腹部彩色多普勒超声检查阳性86例（43.0%），对照组阳性47例（23.5%），观察组高于对照组（χ2=16.2122，P=0.0001），两组阳性病例中单纯性脂肪肝比例均为最高，分别为48.2%和40.0%，观察组脂肪肝发生率高于对照组（χ2=9.8304，P=0.0017），其余各项两组比较差异均无统计学意义（P>0.05）；精神分裂症患者腹部彩色多普勒超声检查阳性率比较，50岁以上患者高于50岁以下患者，用药时间10年以上患者高于2～10年患者，联合用药患者高于单一用药患者，差异均有统计学意义（P<0.05）。结论精神分裂症患者长期用药过程中可能存在内脏损害，对这类人群应定期进行腹部彩色多普勒超声检查，对药物性内脏损害及时发现、早期治疗。
目的：探討長期應用抗精神病藥物的精神分裂癥患者腹腔髒器異常改變情況。方法對2011年6月-2013年8月在本院各箇病區住院的200精神分裂癥患者（觀察組）進行腹部綵色多普勒超聲檢查，併與200例健康體檢者(對照組)進行對比分析。比較兩組研究對象腹部綵色多普勒超聲檢查暘性率，併比較不同年齡、不同用藥時間、不同用藥方式及不同性彆精神分裂癥患者腹部綵色多普勒超聲檢查暘性率。結果觀察組腹部綵色多普勒超聲檢查暘性86例（43.0%），對照組暘性47例（23.5%），觀察組高于對照組（χ2=16.2122，P=0.0001），兩組暘性病例中單純性脂肪肝比例均為最高，分彆為48.2%和40.0%，觀察組脂肪肝髮生率高于對照組（χ2=9.8304，P=0.0017），其餘各項兩組比較差異均無統計學意義（P>0.05）；精神分裂癥患者腹部綵色多普勒超聲檢查暘性率比較，50歲以上患者高于50歲以下患者，用藥時間10年以上患者高于2～10年患者，聯閤用藥患者高于單一用藥患者，差異均有統計學意義（P<0.05）。結論精神分裂癥患者長期用藥過程中可能存在內髒損害，對這類人群應定期進行腹部綵色多普勒超聲檢查，對藥物性內髒損害及時髮現、早期治療。
목적：탐토장기응용항정신병약물적정신분렬증환자복강장기이상개변정황。방법대2011년6월-2013년8월재본원각개병구주원적200정신분렬증환자（관찰조）진행복부채색다보륵초성검사，병여200례건강체검자(대조조)진행대비분석。비교량조연구대상복부채색다보륵초성검사양성솔，병비교불동년령、불동용약시간、불동용약방식급불동성별정신분렬증환자복부채색다보륵초성검사양성솔。결과관찰조복부채색다보륵초성검사양성86례（43.0%），대조조양성47례（23.5%），관찰조고우대조조（χ2=16.2122，P=0.0001），량조양성병례중단순성지방간비례균위최고，분별위48.2%화40.0%，관찰조지방간발생솔고우대조조（χ2=9.8304，P=0.0017），기여각항량조비교차이균무통계학의의（P>0.05）；정신분렬증환자복부채색다보륵초성검사양성솔비교，50세이상환자고우50세이하환자，용약시간10년이상환자고우2～10년환자，연합용약환자고우단일용약환자，차이균유통계학의의（P<0.05）。결론정신분렬증환자장기용약과정중가능존재내장손해，대저류인군응정기진행복부채색다보륵초성검사，대약물성내장손해급시발현、조기치료。
Objective To explore the abnormal changes of abdominal viscera in schizophrenic patients treated with long-term antipsychotics. Methods 242 patients with schizophrenia hospitalized in our hospital from February, 2007 to August, 2013 were examined by abdominal ultrasonography, and compared with 242 healthy persons. Compared the positive rate of abdominal ultrasonography, and compared different ages, different administration time, different treatment Methods and spirit positive rate of different sex. Results Abdominal ultrasound examination was positive in 86 patients in the observation group (43.0%), 47 cases in the control group were positive (23.5%), the observation group was higher than the control group (χ2=16.2122, P=0.0001), positive cases of simple fatty liver was the highest, they were 48.2%and 40%, the incidence of fatty liver of the observation group was higher than that of the control group (χ2=9.8304,P=0.0017), the difference had no statistical significance(P>0.05);Compared the positive rate of abdominal ultrasound examination in the schizophrenic patients, the patients aged over 50 was higher than that of patients under the age of 50, medication time more than 10 years was higher than that of patients with medicine 2-10 years, patients with combined medication were higher than that of single drug, the differences were statistically significance (P<0.05).Conclusion It may injury viscus organs that schizophrenic patients long-term use medication, these people should be regularly examined abdominal ultrasound, and find the visceral damage caused by drug in time, and early treated.
