CAJ | 학술논문

目的：探讨乳腺癌组织FoxP3、TGF-β1的表达和上皮间质转化（EMT）的相互关系及其临床意义。方法：免疫组织化学法检测74例乳腺癌组织中FoxP3、TGF-β1、E-Cadherin、N-Cadherin、Vimentin和Fibronectin的表达情况，分析乳腺癌FoxP3蛋白表达与临床病理特征的关系，以及FoxP3、TGF-β1的表达和EMT发生之间的关系。结果：FoxP3与TGF-β1的表达率和EMT的发生率分别为36.5%（27/74）、39.2%（29/74）和40.5%（30/74）。乳腺癌FoxP3表达与淋巴结转移相关（P<0.05），与其他临床病理特征无关（P>0.05）。FoxP3和TGF-β1的表达之间存在相关性，而TGF-β1可以促进EMT发生（P<0.05）。结论：FoxP3的表达与乳腺癌淋巴结转移和EMT的发生相关，可能作为预测乳腺癌转移可能性的标记物。
목적：탐토유선암조직FoxP3、TGF-β1적표체화상피간질전화（EMT）적상호관계급기림상의의。방법：면역조직화학법검측74례유선암조직중FoxP3、TGF-β1、E-Cadherin、N-Cadherin、Vimentin화Fibronectin적표체정황，분석유선암FoxP3단백표체여림상병리특정적관계，이급FoxP3、TGF-β1적표체화EMT발생지간적관계。결과：FoxP3여TGF-β1적표체솔화EMT적발생솔분별위36.5%（27/74）、39.2%（29/74）화40.5%（30/74）。유선암FoxP3표체여림파결전이상관（P<0.05），여기타림상병리특정무관（P>0.05）。FoxP3화TGF-β1적표체지간존재상관성，이TGF-β1가이촉진EMT발생（P<0.05）。결론：FoxP3적표체여유선암림파결전이화EMT적발생상관，가능작위예측유선암전이가능성적표기물。
Objective: This study aims to investigate the correlation between the expression of FoxP3, TGF-β1, and epitheli-al-mesenchymal transition (EMT) in breast cancer and to determine the clinical significance of FoxP3. Methods: The expression of FoxP3, TGF-β1, E-Cadherin, N-Cadherin, Vimentin, and Fibronectin protein were detected in the cancer cells of 74 cases with breast carcinoma via immunohistochemistry. The correlation of FoxP3 protein with clinico-pathologic features of breast carcinoma and the re-lationships among the expressions of FoxP3, TGF-β1, and epithelial-mesenchymal transition (EMT) were analyzed. Results:The ex-pression rates of FoxP3, TGF-β1, and EMT are 36.5%(27/74), 39.2%(29/74), and 40.5%(30/74), respectively. The FoxP3 protein ex-pression in breast cancer is correlated with lymph node metastasis (P<0.05) but not with other clinico-pathological features (P>0.05). The expression of FoxP3 is also correlated with the expression of TGF-β1. Furthermore, TGF-β1 can induce EMT (P<0.05). Conclu-sion:The expression of FoxP3 is correlated with lymph node metastasis and EMT in breast cancer. Therefore, FoxP3 may be a marker for predicting metastasis.