CAJ | 학술논문

目的：运用超声造影定量分析技术监测丹参治疗兔肾缺血再灌注损伤前后肾皮质血流灌注的变化，探讨超声造影在评价药物治疗肾缺血再灌注损伤疗效中的应用价值。方法家兔切除右肾，夹闭左肾肾蒂缺血60 min后恢复灌注建立兔左肾缺血再灌注损伤模型，并给予丹参注射液对比观察左肾病理改变及在超声造影下肾皮质血流灌注并应用时间-强度曲线定量分析肾皮质血流灌注参数。结果缺血再灌注损伤后，兔肾皮质时间-强度曲线上升缓慢，峰值灌注时间延长，曲线上升支斜率下降（P＜0．05）；经丹参治疗后峰值灌注明显缩短，曲线上升支斜率明显上升（P＜0．05）。结论超声造影定量分析技术能反映兔肾缺血再灌注损伤所致的肾血流灌注异常，并能发现经药物治疗后兔肾血流再灌注的改变。
목적：운용초성조영정량분석기술감측단삼치료토신결혈재관주손상전후신피질혈류관주적변화，탐토초성조영재평개약물치료신결혈재관주손상료효중적응용개치。방법가토절제우신，협폐좌신신체결혈60 min후회복관주건립토좌신결혈재관주손상모형，병급여단삼주사액대비관찰좌신병리개변급재초성조영하신피질혈류관주병응용시간-강도곡선정량분석신피질혈류관주삼수。결과결혈재관주손상후，토신피질시간-강도곡선상승완만，봉치관주시간연장，곡선상승지사솔하강（P＜0．05）；경단삼치료후봉치관주명현축단，곡선상승지사솔명현상승（P＜0．05）。결론초성조영정량분석기술능반영토신결혈재관주손상소치적신혈류관주이상，병능발현경약물치료후토신혈류재관주적개변。
Objective To apply the real-time gray scale contrast-enhanced ultrasonography(CEUS) with quantitative analysis technique to monitor the change of the renal cortex blood perfusion before and after Salvia miltiorrhiza treatment of rabbit renal is-chemia-reperfusion injury and to investigate the application value of the ultrasound contrast for evaluating the effect of medication in the treatment of rabbit renal ischemia-reperfusion injury (IRI) .Methods The rabbit right kidney was resected and the left renal pedicle was occluded for 60 min ischemia ,then the perfusion was recovered for establishing the IRI model .Salvia miltiorrhiza injec-tion was given for observing the pathological changes of the left kidney and the renal cortex blood prefusion under the contrast-en-hanced ultrasonography .The parameters of renal cortex blood perfusion were quantitatively analyzed by the time-intension curves . Results After IRI occurrence ,the time-intensity curve (TIC) of the rabbit renal cortex was slowly ascended .The time to peak (TTP) was extened and the rising slope(Grad) of the curve ascending branch was declined (P< 0 .05);after Salvia miltiorrhiza treatment ,TTP decreased and Grad increased obviously(P<0 .05) .Conclusion CEUS combined with quantitative analysis can re-flect the renal blood perfusion abnormity caused by ischemia-reperfusion and discover the change of the renal blood perfusion after medication treatment .