重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
2期
158-160
,共3页
杨军%王光辉%丁赛良%王苏燕%邝孛%邓彪%褚春%江振涛%格波
楊軍%王光輝%丁賽良%王囌燕%鄺孛%鄧彪%褚春%江振濤%格波
양군%왕광휘%정새량%왕소연%광패%산표%저춘%강진도%격파
冠心病%leptin%Gensini评分%危险分层%生化标记物
冠心病%leptin%Gensini評分%危險分層%生化標記物
관심병%leptin%Gensini평분%위험분층%생화표기물
coronary heart disease%leptin%Gensini score%risk stratification%biochemical markers
目的：观察不同危险分层冠心病患者血清瘦素（leptin ）水平的变化，探讨血清 leptin浓度与冠脉病变程度和冠脉Gensini评分的相关性及其在冠心病危险分层中的价值。方法120例研究对象分为4组，分别为非冠心病组，稳定性心绞痛（SAP）组，不稳定性心绞痛（UAP）组及心肌梗死（AMI）组，检测并分析各组leptin水平与冠心病危险因素、危险评估生化标志物的相关性。结果 AMI组血清leptin水平显著高于非冠心病组和SAP组，leptin水平随着冠脉病变程度及Gensini积分的增加有逐步上升趋势，并与常用冠心病危险分层指标心肌肌钙蛋白、吸烟指数呈线性正相关，与血尿酸呈负相关。结论 leptin水平可作为评估急性冠脉事件发生有价值的标志物，并与常用冠心病危险分层生化标志物及冠脉病变程度具有较好的相关性。
目的：觀察不同危險分層冠心病患者血清瘦素（leptin ）水平的變化，探討血清 leptin濃度與冠脈病變程度和冠脈Gensini評分的相關性及其在冠心病危險分層中的價值。方法120例研究對象分為4組，分彆為非冠心病組，穩定性心絞痛（SAP）組，不穩定性心絞痛（UAP）組及心肌梗死（AMI）組，檢測併分析各組leptin水平與冠心病危險因素、危險評估生化標誌物的相關性。結果 AMI組血清leptin水平顯著高于非冠心病組和SAP組，leptin水平隨著冠脈病變程度及Gensini積分的增加有逐步上升趨勢，併與常用冠心病危險分層指標心肌肌鈣蛋白、吸煙指數呈線性正相關，與血尿痠呈負相關。結論 leptin水平可作為評估急性冠脈事件髮生有價值的標誌物，併與常用冠心病危險分層生化標誌物及冠脈病變程度具有較好的相關性。
목적：관찰불동위험분층관심병환자혈청수소（leptin ）수평적변화，탐토혈청 leptin농도여관맥병변정도화관맥Gensini평분적상관성급기재관심병위험분층중적개치。방법120례연구대상분위4조，분별위비관심병조，은정성심교통（SAP）조，불은정성심교통（UAP）조급심기경사（AMI）조，검측병분석각조leptin수평여관심병위험인소、위험평고생화표지물적상관성。결과 AMI조혈청leptin수평현저고우비관심병조화SAP조，leptin수평수착관맥병변정도급Gensini적분적증가유축보상승추세，병여상용관심병위험분층지표심기기개단백、흡연지수정선성정상관，여혈뇨산정부상관。결론 leptin수평가작위평고급성관맥사건발생유개치적표지물，병여상용관심병위험분층생화표지물급관맥병변정도구유교호적상관성。
Objective To observe the change of serum leptin in different risk stratifications of coronary heart disease (CHD) and to investigate its relationship with the severity of coronary artery lesion and the coronary artery Gensini score and its value in the coronary heart disease risk stratification .Methods According to coronary angiography ,120 research subjects were enrolled and di-vided into 4 groups :the non-CHD group ,stable angina(SAP) group ,unstable angina pectoris(UAP) group and myocardial infarc-tion group(AMI) ,respectively .The serum leptin levels in 4 groups were determined by immunoassay and the correlation between the leptin level with the coronary heart disease risk factor and biochemical markers of risk assessment was analyzed .Results The serum leptin level in the AMI group was significantly higher than that in the non-CHD group and the SAP group ,the leptin level showed the increasing trend with the increase of the coronary lesion severity and the Gensini scores and was positively related with the CHD risk stratification indicators cTnT and smoking index ,and negatively related with blood uric acid .Conclusion The serum leptin may be used as the valuable marker for evaluating the occurrence of acute coronary event and has good correlation with usual biochemical markers of CHD risk stratification and the severity of coronary artery lesion .
