CAJ | 학술논문

目的：探究鼻咽癌患者接受放疗后肿瘤退缩速度对于其预后的影响状况。方法选自本院2009年至2011年收治的鼻咽癌患者肿瘤快速退缩、缓慢退缩以及残留患者各100例，患者的原发肿瘤和转移淋巴结受体外照射的处方剂量在66~72 Gy，颈部受预防剂量在50~52 Gy。肿瘤在照射剂量＜50 Gy时全退缩为快速退缩，在50~70 Gy的为缓慢退缩，超过70 Gy的定义为残留。对患者应用Cox回归模型进行分析，使用Kaplan-Meier方法进行生存分析。结果三组患者的5年生存率分别为64.0%、72.0%和49.0%；无病生存率分别为60.0%、72.0%以及29.0%。对患者进行多因素分析，认为对其预后有直接影响的因素有：N分期、T分期以及肿瘤退缩速度。结论鼻咽癌患者接受根治性放疗治疗过程中，自身的5年生存率、无病生存率等受到肿瘤退缩速度影响，其中以缓慢退缩的预后效果最佳。
목적：탐구비인암환자접수방료후종류퇴축속도대우기예후적영향상황。방법선자본원2009년지2011년수치적비인암환자종류쾌속퇴축、완만퇴축이급잔류환자각100례，환자적원발종류화전이림파결수체외조사적처방제량재66~72 Gy，경부수예방제량재50~52 Gy。종류재조사제량＜50 Gy시전퇴축위쾌속퇴축，재50~70 Gy적위완만퇴축，초과70 Gy적정의위잔류。대환자응용Cox회귀모형진행분석，사용Kaplan-Meier방법진행생존분석。결과삼조환자적5년생존솔분별위64.0%、72.0%화49.0%；무병생존솔분별위60.0%、72.0%이급29.0%。대환자진행다인소분석，인위대기예후유직접영향적인소유：N분기、T분기이급종류퇴축속도。결론비인암환자접수근치성방료치료과정중，자신적5년생존솔、무병생존솔등수도종류퇴축속도영향，기중이완만퇴축적예후효과최가。
Objective To explore the effect of patients with nasopharyngeal carcinomatumor regression speed for its prognosis after radiotherapy. Methods The patients with nasopharyngeal carcinoma tumor in our hospital from 2005-2008 years were selected from the rapid retreat, slow retreat and residue of the 100 cases of patients, patients with primary tumor and metastatic lymph nodes by in vitro irradiation dose between 65-70Gy, the neck by the prophylactic dose between 50-55Gy. Completely shrink faster than 50Gy for the rapid withdrawal, withdrawal speed between 50-70Gy slow retreat, deifned over 70Gy for residual. For patients with Cox regression model, using the Kaplan-Meier method was used for survival analysis. Results 5 year survival rate in patients of the three groups were 64%, 72%and 49%;disease free survival rates were 60%, 72%and 29%. Multivariate analysis was performed on patients, factors that are directly linked to the prognosis:N staging, T staging and tumor regression speed. Conclusion Nasopharyngeal carcinoma patients received radical radiotherapy treatment process, the 5 year survival rate, disease free survival rate by tumor regression speed effect, the prognosis effect to slow retreat of the best.