中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
8期
1553-1556
,共4页
刘军才%孙燕来%张毅
劉軍纔%孫燕來%張毅
류군재%손연래%장의
血小板源性生长因子%受体,血小板源生长因子%胃肿瘤%分子靶向治疗
血小闆源性生長因子%受體,血小闆源生長因子%胃腫瘤%分子靶嚮治療
혈소판원성생장인자%수체,혈소판원생장인자%위종류%분자파향치료
Platelet derived growth factor%Receptors,platelet-derived growth factor%Stomach neoplasms%Molecular targeting treatment
血小板源性生长因子(PDGF)及其受体与肿瘤的发生、新生血管的生成、控制肿瘤组织间隙压以及细胞凋亡机制等密切相关。新近研究发现,通过靶向抑制PDGF及其受体能够抑制胃癌的新血管生成和增强细胞毒性化疗药物的疗效。现综述PDGF及其受体在胃癌分子靶向治疗方面的研究进展。
血小闆源性生長因子(PDGF)及其受體與腫瘤的髮生、新生血管的生成、控製腫瘤組織間隙壓以及細胞凋亡機製等密切相關。新近研究髮現,通過靶嚮抑製PDGF及其受體能夠抑製胃癌的新血管生成和增彊細胞毒性化療藥物的療效。現綜述PDGF及其受體在胃癌分子靶嚮治療方麵的研究進展。
혈소판원성생장인자(PDGF)급기수체여종류적발생、신생혈관적생성、공제종류조직간극압이급세포조망궤제등밀절상관。신근연구발현,통과파향억제PDGF급기수체능구억제위암적신혈관생성화증강세포독성화료약물적료효。현종술PDGF급기수체재위암분자파향치료방면적연구진전。
Platelet derived growth factor (PDGF) and its receptor are closely related to the mechanism of tumorigenesis, angiogenesis, tumor formation, tumor interstitial pressure and cell apoptosis mechanism. Recent researches have found that targeted inhibition of PDGF and its receptors could inhibit angiogenesis of gastric cancer and enhance the effect of cytotoxic chemotherapy. We reviewed the progress of PDGF and its receptor in the molecular targeting treatment of gastric cancer.