中国生育健康杂志
中國生育健康雜誌
중국생육건강잡지
CHINESE JOURNAL OF REPRODUCTIVE HEALTH
2014年
3期
223-225,248
,共4页
尹红燕%刘玉珍%吕秀萍%张鹏%孙小云
尹紅燕%劉玉珍%呂秀萍%張鵬%孫小雲
윤홍연%류옥진%려수평%장붕%손소운
抗苗勒管激素%卵巢功能%子宫全切术%卵泡刺激素%黄体生成素%雌二醇
抗苗勒管激素%卵巢功能%子宮全切術%卵泡刺激素%黃體生成素%雌二醇
항묘륵관격소%란소공능%자궁전절술%란포자격소%황체생성소%자이순
Anti-Mullerian hormone%Ovarian function%Hysterectomy%Follicle-stimulating hormone%Luteinizing hormone%Estradiol
目的：研究抗苗勒管激素（AMH）在子宫全切术后卵巢功能变化监测中的意义，探讨子宫全切对卵巢功能的影响。方法选取因子宫肌瘤和子宫腺肌病行腹腔镜下子宫全切术并保留双侧附件的患者30例（全切组）和同期健康妇女30例（对照组），测定患者血清中的 AMH、卵泡刺激素（FSH）、黄体生成素（LH）和雌二醇（E2）水平和同时经阴道超声测量卵巢体积（OV）和卵巢间质动脉的阻力指数（RI），比较两组水平。结果全切组 AMH、FSH、LH 和 E2术前[（1.49±075）μg/L、（9.45±4.05）U /L、（10.02±7.90）U /L、（55.55±14.68）ng/L]与术后1个月[（1.10±0.48）μg/L、（12.44±6.76）U /L、（13.97±7.28）U /L、（44.45±13.81）ng/L]比较，全切组术后6个月 AMH[（0.72±0.59）μg/L]与术前比较，全切组术后1个月 AMH、FSH、LH 和 E2与对照组1个月后[（1.47±0.75）μg/L、（9.56±3.61）U /L、（9.94±6.04）U /L、（51.53±14.60）ng/L]比较，全切组术后6个月 AMH与对照组6个月[（1.46±0.83）μg/L]比较，全切组 OV 和 RI 术前[（6.63±2.37）cm、（0.59±0.20）]与术后1个月[（3.57±1.03）cm、（0.73±0.08）]比较，全切组 OV 和 RI 术后1个月与对照组1个月[（6.71±2.36）cm、（0.69±0.21）]比较，差异均有统计学意义。结论子宫全切术对卵巢功能近期有影响，AMH 是监测卵巢功能变化更可靠、更敏感的指标。
目的：研究抗苗勒管激素（AMH）在子宮全切術後卵巢功能變化鑑測中的意義，探討子宮全切對卵巢功能的影響。方法選取因子宮肌瘤和子宮腺肌病行腹腔鏡下子宮全切術併保留雙側附件的患者30例（全切組）和同期健康婦女30例（對照組），測定患者血清中的 AMH、卵泡刺激素（FSH）、黃體生成素（LH）和雌二醇（E2）水平和同時經陰道超聲測量卵巢體積（OV）和卵巢間質動脈的阻力指數（RI），比較兩組水平。結果全切組 AMH、FSH、LH 和 E2術前[（1.49±075）μg/L、（9.45±4.05）U /L、（10.02±7.90）U /L、（55.55±14.68）ng/L]與術後1箇月[（1.10±0.48）μg/L、（12.44±6.76）U /L、（13.97±7.28）U /L、（44.45±13.81）ng/L]比較，全切組術後6箇月 AMH[（0.72±0.59）μg/L]與術前比較，全切組術後1箇月 AMH、FSH、LH 和 E2與對照組1箇月後[（1.47±0.75）μg/L、（9.56±3.61）U /L、（9.94±6.04）U /L、（51.53±14.60）ng/L]比較，全切組術後6箇月 AMH與對照組6箇月[（1.46±0.83）μg/L]比較，全切組 OV 和 RI 術前[（6.63±2.37）cm、（0.59±0.20）]與術後1箇月[（3.57±1.03）cm、（0.73±0.08）]比較，全切組 OV 和 RI 術後1箇月與對照組1箇月[（6.71±2.36）cm、（0.69±0.21）]比較，差異均有統計學意義。結論子宮全切術對卵巢功能近期有影響，AMH 是鑑測卵巢功能變化更可靠、更敏感的指標。
목적：연구항묘륵관격소（AMH）재자궁전절술후란소공능변화감측중적의의，탐토자궁전절대란소공능적영향。방법선취인자궁기류화자궁선기병행복강경하자궁전절술병보류쌍측부건적환자30례（전절조）화동기건강부녀30례（대조조），측정환자혈청중적 AMH、란포자격소（FSH）、황체생성소（LH）화자이순（E2）수평화동시경음도초성측량란소체적（OV）화란소간질동맥적조력지수（RI），비교량조수평。결과전절조 AMH、FSH、LH 화 E2술전[（1.49±075）μg/L、（9.45±4.05）U /L、（10.02±7.90）U /L、（55.55±14.68）ng/L]여술후1개월[（1.10±0.48）μg/L、（12.44±6.76）U /L、（13.97±7.28）U /L、（44.45±13.81）ng/L]비교，전절조술후6개월 AMH[（0.72±0.59）μg/L]여술전비교，전절조술후1개월 AMH、FSH、LH 화 E2여대조조1개월후[（1.47±0.75）μg/L、（9.56±3.61）U /L、（9.94±6.04）U /L、（51.53±14.60）ng/L]비교，전절조술후6개월 AMH여대조조6개월[（1.46±0.83）μg/L]비교，전절조 OV 화 RI 술전[（6.63±2.37）cm、（0.59±0.20）]여술후1개월[（3.57±1.03）cm、（0.73±0.08）]비교，전절조 OV 화 RI 술후1개월여대조조1개월[（6.71±2.36）cm、（0.69±0.21）]비교，차이균유통계학의의。결론자궁전절술대란소공능근기유영향，AMH 시감측란소공능변화경가고、경민감적지표。
Objective To investigate the value of anti-Mullerian hormone (AMH)in evaluating ovarian function after total hysterectomy and the influence of total hysterectomy on ovarian function. Methods This study was conducted at the affiliated hospital of Weifang Medical College between February and November 2013.Thirty patients aged 40 and 50 years who underwent laparoscopic total hysterectomy for benign uterine diseases were enrolled into the case group and unaffected women in a similar age range constituted the control group.Serum levels of AMH,follicle-stimulating hormone (FSH),luteinizing hormone (LH)and estradiol (E2 )were assayed on the 7th to 10th day of menstruation before operation,at 1st month and 6th month of operation,respectively.At the same time,ovarian volume (OV)and ovarian stromal artery resistance index (RI)were measured through transvaginal ultrasound. Results In the case group,there were significant differences between pre-operation and at 1st month of operation in AMH [(1.49 ±075)μg/L vs.(1.10 ± 0.48)μg/L],FSH [(9.45 ±4.05)U /L vs.(12.44 ±6.76)U /L],LH [(10.02 ±7.90)U /L vs.(13.97 ±7.28) U /L],E2 [(55.55 ±14.68)ng/L vs.(44.45 ±13.81)ng/L],OV [(6.63 ±2.37)cm vs.(3.57 ±1.03)cm,and FI [(0.59 ±0.20)vs.(0.73 ±0.08)].However,only AMH levels showed a statistical significance between pre-operation and at 6th month of operation [(0.72 ±0.59)μg/L].In the control group,Levels of AMH,FSH,LH and E2 levels,OV and RI at 1st and 6th month of operation were insignificantly difference compared with preoperative levels. There were significant differences at 1st month of operation between the case group and the control group in AMH [(1.47 ± 0.75)μg/L,FSH (9.56 ±3.61)U /L,LH (9.94 ±6.04)U /L,E2 (51.53 ±14.60)ng/L],OV [(6.71 ±2.36)cm, and RI (0.69 ±0.21)].Only AMH level was significant different between case group and control group [(1.46 ±0.83)μg/L]at 6th month of operation. Conclusion It appears that total hysterectomy causes more or less loss of ovarian reserve function.AMH was a more reliable and sensitive index for evaluating ovarian function.
