当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2014年
3期
1-2
,共2页
幽门螺杆菌%细胞毒素相关蛋白%胃癌
幽門螺桿菌%細胞毒素相關蛋白%胃癌
유문라간균%세포독소상관단백%위암
Heiliobacter pylori%CagA%Gastric cancer
目的：探讨吉林省延边地区朝鲜族与汉族之间幽门螺杆菌（Helicobacter pylori Hp）细胞毒素相关基因与胃癌及癌前疾病的相关性。方法Hp检查阳性患者571例（朝257例，汉314例），慢性浅表性胃炎组（CSG）168例（朝75例，汉93例）、慢性萎缩性胃炎组（CAG）167例(朝76例，汉91例)、胃溃疡（GU）组132例(朝60例，汉72例)，胃癌组（GC）104例(朝46例，汉58例)。采用快速尿素酶法、14 C呼气试验法、免疫印迹法检测定细胞毒素相关基因蛋白(CagA)菌株感染率。结果（1）朝鲜族与汉族CagA基因菌株阳性率比较差异有统计学意义(P=0.004＜0.05)。（2）在朝鲜族组中胃癌组、胃溃疡、萎缩性胃炎组与均较浅表性胃炎组CagA基因菌株阳性率高(P＜0.05)。同样，在汉族组中胃癌组、胃溃疡、萎缩性胃炎组与也均较浅表性胃炎组CagA基因菌株阳性率高(P＜0.05)。（3）朝鲜族胃癌组CagA基因菌株阳性率低于汉族胃癌组(P=0.019＜0.05)。结论（1）朝鲜族CagA基因菌株阳性率较汉族患者低。（2）感染CagA基因菌株易引起严重的炎症反应，与胃癌、胃溃疡及慢性萎缩性胃炎关系密切。（3）朝鲜族患者胃癌的发生与CagA基因菌株感染相关性较汉族患者小。
目的：探討吉林省延邊地區朝鮮族與漢族之間幽門螺桿菌（Helicobacter pylori Hp）細胞毒素相關基因與胃癌及癌前疾病的相關性。方法Hp檢查暘性患者571例（朝257例，漢314例），慢性淺錶性胃炎組（CSG）168例（朝75例，漢93例）、慢性萎縮性胃炎組（CAG）167例(朝76例，漢91例)、胃潰瘍（GU）組132例(朝60例，漢72例)，胃癌組（GC）104例(朝46例，漢58例)。採用快速尿素酶法、14 C呼氣試驗法、免疫印跡法檢測定細胞毒素相關基因蛋白(CagA)菌株感染率。結果（1）朝鮮族與漢族CagA基因菌株暘性率比較差異有統計學意義(P=0.004＜0.05)。（2）在朝鮮族組中胃癌組、胃潰瘍、萎縮性胃炎組與均較淺錶性胃炎組CagA基因菌株暘性率高(P＜0.05)。同樣，在漢族組中胃癌組、胃潰瘍、萎縮性胃炎組與也均較淺錶性胃炎組CagA基因菌株暘性率高(P＜0.05)。（3）朝鮮族胃癌組CagA基因菌株暘性率低于漢族胃癌組(P=0.019＜0.05)。結論（1）朝鮮族CagA基因菌株暘性率較漢族患者低。（2）感染CagA基因菌株易引起嚴重的炎癥反應，與胃癌、胃潰瘍及慢性萎縮性胃炎關繫密切。（3）朝鮮族患者胃癌的髮生與CagA基因菌株感染相關性較漢族患者小。
목적：탐토길림성연변지구조선족여한족지간유문라간균（Helicobacter pylori Hp）세포독소상관기인여위암급암전질병적상관성。방법Hp검사양성환자571례（조257례，한314례），만성천표성위염조（CSG）168례（조75례，한93례）、만성위축성위염조（CAG）167례(조76례，한91례)、위궤양（GU）조132례(조60례，한72례)，위암조（GC）104례(조46례，한58례)。채용쾌속뇨소매법、14 C호기시험법、면역인적법검측정세포독소상관기인단백(CagA)균주감염솔。결과（1）조선족여한족CagA기인균주양성솔비교차이유통계학의의(P=0.004＜0.05)。（2）재조선족조중위암조、위궤양、위축성위염조여균교천표성위염조CagA기인균주양성솔고(P＜0.05)。동양，재한족조중위암조、위궤양、위축성위염조여야균교천표성위염조CagA기인균주양성솔고(P＜0.05)。（3）조선족위암조CagA기인균주양성솔저우한족위암조(P=0.019＜0.05)。결론（1）조선족CagA기인균주양성솔교한족환자저。（2）감염CagA기인균주역인기엄중적염증반응，여위암、위궤양급만성위축성위염관계밀절。（3）조선족환자위암적발생여CagA기인균주감염상관성교한족환자소。
Objective To study on association of Helicobacter pylori CagA gene of strain with gastric cancer and gastric precancerous disease in chao and han nationalities. Methods In 571 case (chao 257 , han 314) infected by Helicobacer pylori ,contain 172 cases chronic superficial gastritis (CSG)(chao 79, han 93) , 180 cases chronic atrophic gastritis(CAG)(chao 79, han 91),135 cases gastric ulcer(GU)(chao 63, han 72), 94 cases gastric cancer(GC)(chao 36, han 58). CagA in serum were measured by innunoblotting. 14 C urea breath test, Rapid uricase tests used to identify Hp infecrion.Results (1)Positive rates of Hp CagA gene strain in han nationalities were higher than that in chao nationalities,there were difference by statistical comparison (P=0.004<0.05).(2)Positive rates of Hp CagA gene strain in GC,CAG and GU were higher than that in CSG, there were difference by statistical comparison in chao nationalities (P<0.05). Positive rates of Hp CagA gene strain in GC,CAG and GU were higher than that in CSG, there were difference by statistical comparison in han nationalities (P<0.05).(3)Positive rates of Hp CagA gene strain in han nationalities were higher than that in chao nationalities with gastric cancer group,there were difference by statistical comparison (P=0.019<0.05). Conculusion (1)Positive rates of Hp CagA gene strain in han nationalities were higher than that in chao nationalities.(2)The more serious inflammatory reaction were caused by Hp CagA gene strain with CAG, GU and GC.(3)The Hp CagA gene strain played more important roles in chao patients than in han patients of causing gastric cancer.
