重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
3期
298-300,303
,共4页
脱细胞膀胱基质%生物相容性%细胞毒性试验%溶血试验%阴道埋植试验
脫細胞膀胱基質%生物相容性%細胞毒性試驗%溶血試驗%陰道埋植試驗
탈세포방광기질%생물상용성%세포독성시험%용혈시험%음도매식시험
acellular bladder matrix%biocompatibility%cytotoxicity test%hemolysis test%vaginal implant test
目的：评价脱细胞膀胱基质作为盆底修复替代材料的生物相容性。方法通过细胞毒性试验、溶血试验、阴道埋植试验等体内外生物学实验相结合的方法评价该材料的生物相容性。结果在细胞毒性试验中，材料毒性级别0～1级。材料浸提液的溶血率为1．5％。大体和组织学观察示材料未引起宿主免疫排斥反应，植入后引起轻度的异物反应，移植12周后基本降解。结论该材料具有良好的生物相容性，但需调整其降解率，以适应盆底修复手术要求。
目的：評價脫細胞膀胱基質作為盆底脩複替代材料的生物相容性。方法通過細胞毒性試驗、溶血試驗、陰道埋植試驗等體內外生物學實驗相結閤的方法評價該材料的生物相容性。結果在細胞毒性試驗中，材料毒性級彆0～1級。材料浸提液的溶血率為1．5％。大體和組織學觀察示材料未引起宿主免疫排斥反應，植入後引起輕度的異物反應，移植12週後基本降解。結論該材料具有良好的生物相容性，但需調整其降解率，以適應盆底脩複手術要求。
목적：평개탈세포방광기질작위분저수복체대재료적생물상용성。방법통과세포독성시험、용혈시험、음도매식시험등체내외생물학실험상결합적방법평개해재료적생물상용성。결과재세포독성시험중，재료독성급별0～1급。재료침제액적용혈솔위1．5％。대체화조직학관찰시재료미인기숙주면역배척반응，식입후인기경도적이물반응，이식12주후기본강해。결론해재료구유량호적생물상용성，단수조정기강해솔，이괄응분저수복수술요구。
Objective To evaluate the biocompatibility of acellular bladder matrix patch as the pelvic floor repair alternative ma-terial .Methods The combination of in vivo and in vitro biological experiments including cytotoxicity ,haemolysis and vaginal im-plant tests were employed to evaluate the biocompatibility of this material .Results In the cytotoxicity test ,the material toxicity was the grade 0-1 .The hemolysis rate of the material extract liquid was 1 .5% .The general and histological observation showed that the material did not cause the host immunologic rejection and led to slight foreign body reaction after implanting ,which was ba-sically degraded in 12 weeks after transplantation .Conclusion Acellular bladder matrix exhibits better biocompatibility ,but needs to adjust its degradation rate in order to adapt to the requirements of pelvic floor repair operation .
