CAJ | 학술논문

目的：比较坦度螺酮、文拉法辛和劳拉西泮对广泛性焦虑症的疗效、安全性及治疗依从性的差异。方法：将108例广泛性焦虑症患者随机分入坦度螺酮组（36例）、文拉法辛组（36例）和劳拉西泮组（36例），分别给予相应的药物治疗6周，半年后随访。治疗前、治疗后1、2、6周末和半年后随访时应用汉密尔顿焦虑量表（ HAMA）和副反应量表（ TESS）评定疗效和副反应。结果：文拉法辛组和劳拉西泮组患者治疗第1周末HAMA总分较治疗前有显著下降（ P＜0．01），坦度螺酮组患者治疗第2周末HA-MA总分较治疗前有显著下降（P＜0．01）。半年后随访时劳拉西泮组患者HAMA总分显著高于坦度螺酮组和文拉法辛组（P＜0．05）。坦度螺酮组、文拉法辛组和劳拉西泮组的显效率分别为69．4％、72．2％、69．4％、经x2检验差异无显著性（P＞0．05）。坦度螺酮组和文拉法辛组副反应的总发生率均显著低于劳拉西泮组（P＜0．05）。半年后随访时坦度螺酮组和文拉法辛组服药依从性好者显著高于劳拉西泮组（P＜0．05）。结论：坦度螺酮和文拉法辛治疗广泛性焦虑症的短期疗效与劳拉西泮无明显差别，中期疗效和服药依从性明显优于劳拉西泮，副反应的发生率低。
목적：비교탄도라동、문랍법신화로랍서반대엄범성초필증적료효、안전성급치료의종성적차이。방법：장108례엄범성초필증환자수궤분입탄도라동조（36례）、문랍법신조（36례）화로랍서반조（36례），분별급여상응적약물치료6주，반년후수방。치료전、치료후1、2、6주말화반년후수방시응용한밀이돈초필량표（ HAMA）화부반응량표（ TESS）평정료효화부반응。결과：문랍법신조화로랍서반조환자치료제1주말HAMA총분교치료전유현저하강（ P＜0．01），탄도라동조환자치료제2주말HA-MA총분교치료전유현저하강（P＜0．01）。반년후수방시로랍서반조환자HAMA총분현저고우탄도라동조화문랍법신조（P＜0．05）。탄도라동조、문랍법신조화로랍서반조적현효솔분별위69．4％、72．2％、69．4％、경x2검험차이무현저성（P＞0．05）。탄도라동조화문랍법신조부반응적총발생솔균현저저우로랍서반조（P＜0．05）。반년후수방시탄도라동조화문랍법신조복약의종성호자현저고우로랍서반조（P＜0．05）。결론：탄도라동화문랍법신치료엄범성초필증적단기료효여로랍서반무명현차별，중기료효화복약의종성명현우우로랍서반，부반응적발생솔저。
Objective:To compare Tandospirone , Venlafaxine and Lorazepam on efficacy and safety of generalized anxiety and medica -tion adherence.Methods:108 patients with generalized anxiety were randomly assigned to Tandospirone treatment group (36 cases),Ven-lafaxine treatment group(36 cases) and Lorazepam treatment group (36 cases) . All the patients were respectively gave corresponding drug treatment for 6 weeks ,and follewed up after six months .The hamilton Depression Anxiety Scale ( hAMA) and Treatment Emergent Symptoms Scale(TESS) were used to assess the efficacy and side effects .Results:The hAMD scores significantly declined after 1 week end treatment in Venlafaxine group and lorazepam group patients (P<0.01),and the Tandospirone group patients showed significantly de-clined of the hAMA scores after 2 week end (P<0.01).The hAMD scores were significantly higher than Venlafaxine group and Loraze-pam group after six months follow -up (P<0.05).The significant improvement rates of Tandospirone group ,Venlafaxine group and loraz-epam group show 69.4%, 72.2%and 69.4%respectively, there was no significant difference by X2 Test(P>0.05).The incidence of side effects of Tandospirone group and Venlafaxine group were significantly lower than that of lorazepam group (P<0.05).After six months follow-up, the medication adherence of Tandospirone group and Venlafaxine group were significantly higher than that of Loraze -pam group(P<0.05).Conclusion:There was no evident difference on short -term efficacy in the treatment on generalized anxiety of with Lorazepam .But Tandospirone and Venlafaxine had evident better dcurative effect and medication adherence than Lorazepam .and lower in-cidence of adverse events .