CAJ | 학술논문

青光眼是一类复杂的综合征，多种机制参与青光眼视神经损害。近年来，随着对神经退行性疾病和轴突病变研究的重视和深入，轴突变性与青光眼关系的研究也有新的进展。一系列研究结果表明轴突病变-神经元损伤之间的关系在青光眼病变过程中发挥重要作用，认为远端轴突病变可能与青光眼视神经病变有关，其病理基础可能是视觉通路上视神经的逆行性变性过程。本文就远端轴突病变的发病机制及其与青光眼关系的最新研究进展作一简要综述。
청광안시일류복잡적종합정，다충궤제삼여청광안시신경손해。근년래，수착대신경퇴행성질병화축돌병변연구적중시화심입，축돌변성여청광안관계적연구야유신적진전。일계렬연구결과표명축돌병변-신경원손상지간적관계재청광안병변과정중발휘중요작용，인위원단축돌병변가능여청광안시신경병변유관，기병리기출가능시시각통로상시신경적역행성변성과정。본문취원단축돌병변적발병궤제급기여청광안관계적최신연구진전작일간요종술。
Glaucoma is a complex class of degenerative optic neuropathy.Multiple mechanisms were involved in glaucomatous optic nerve damage.In recent years , research progression has been made in the relationship between axonal degeneration and glaucoma with more attention and effort dedicated to explicate the pathogenesis of progressive optic nerve injury.Series of studies indicate that the interplay between distal axonal degeneration and axon neuron damage may play an important role in the progression of the disease.Distal axonal lesions may contribute to glaucoma , the pathological basis may be the retrograde degeneration of the optic nerve in visual pathways.In this article , we review the latest findings in the distal axonal degeneration and glaucomatous optic neuropathy.