CAJ | 학술논문

目的：评价放化疗联合热疗治疗鼻咽癌颈部淋巴结转移的临床疗效。方法选取2006年-2007年我院收治的鼻咽癌伴颈部淋巴结转移二程诱导化疗后有淋巴结残留的患者33例。诱导化疗采用顺铂联合5-氟尿嘧啶化疗，每3周一次，共2次。诱导化疗后有残留的随机分为观察组和对照组。其中对照组17例，用单药顺铂联合常规放疗，观察组16例，放化疗措施同对照组，放疗前对病灶给予局部热疗。观察并比较两组患者颈部淋巴结消退情况、治疗后生存率及放化疗毒性反应。结果观察组采用放化疗联合热疗，总有效率为100%，对照组采用单纯放化疗治疗，总有效率为88.23%，相比较差异有统计学意义(P＜0.05)；观察组治疗后3年生存率(81.25%)及5年的生存率(56.25%)与对照组治疗后3年的生存率(64.71%)及5年的生存率(41.18%)相比较差异有统计学意义，P＜0.05；观察组不良反应发生率为6.25%，对照组不良反应发生率为11.8%，相比较差异无统计学意义( P＜0.05)。结论放化疗联合热疗治疗鼻咽癌颈部淋巴结转移疗效好，值得在临床上予以推广。
목적：평개방화료연합열료치료비인암경부림파결전이적림상료효。방법선취2006년-2007년아원수치적비인암반경부림파결전이이정유도화료후유림파결잔류적환자33례。유도화료채용순박연합5-불뇨밀정화료，매3주일차，공2차。유도화료후유잔류적수궤분위관찰조화대조조。기중대조조17례，용단약순박연합상규방료，관찰조16례，방화료조시동대조조，방료전대병조급여국부열료。관찰병비교량조환자경부림파결소퇴정황、치료후생존솔급방화료독성반응。결과관찰조채용방화료연합열료，총유효솔위100%，대조조채용단순방화료치료，총유효솔위88.23%，상비교차이유통계학의의(P＜0.05)；관찰조치료후3년생존솔(81.25%)급5년적생존솔(56.25%)여대조조치료후3년적생존솔(64.71%)급5년적생존솔(41.18%)상비교차이유통계학의의，P＜0.05；관찰조불량반응발생솔위6.25%，대조조불량반응발생솔위11.8%，상비교차이무통계학의의( P＜0.05)。결론방화료연합열료치료비인암경부림파결전이료효호，치득재림상상여이추엄。
Objective : To evaluate chemotherapy combined with hyperthermia treatment of metastatic cervical lymph node metastasis in clinical efficacy. Methods: 2006 to 2007 in our hospital nasopharyngeal carcinoma with cervical lymph node metastasis in patients with residual two -way 33 patients after induction chemotherapy. Induction chemotherapy using cisplatin in combination with 5 - fluorouracil chemotherapy once every three weeks , a total of 2 times. After induction chemotherapy were randomly divided into observation residual group and the control group . Among the control group 17 cases , with single-agent cisplatin conventional radiotherapy , the observation group 16 cases , chemotherapy measures with the control group , given before radiotherapy for lesions localized hyperthermia. Comparison of the two groups were observed and regression of cervical lymph nodes , survival and toxicity after chemotherapy treatment . Results: The study group using chemotherapy combined with hyperthermia , the total effective rate was 100 % in the control group were treated with radiotherapy and chemotherapy alone , the total effective rate was 88.23% , compared to the difference was statistical y significant (P <0.05); observation group after treatment 3 -year survival rate ( 81.25% ) and 5-year survival rate ( 56.25% ) after treatment with the control group, 3 -year survival rate ( 64.71% ) and 5-year survival rate ( 41.18% ) compared to the difference was statistical y significant , P <0.05; adverse reactions observed group was 6.25 % in the control group of adverse reactions was 11.8% , compared with no significant difference (P <0.05). Conclusion: chemotherapy combined with hyperthermia therapy is effective cervical lymph node metastasis of nasopharyngeal carcinoma deserves to be promoted in clinical practice.