中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
34期
323-325
,共3页
急性心肌梗死%脑钠肽%早期
急性心肌梗死%腦鈉肽%早期
급성심기경사%뇌납태%조기
Acute myocardial infarction%Brain natriuretic peptide%Early stage
目的：分析急性心肌梗死早期血浆脑钠肽水平的变换情况，为临床治疗积累经验。方法选择稳定型心绞痛（SA）患者、不稳定型心绞痛（UA）患者及健康对照组各20例测定血浆BNP浓度，急性心肌梗死（AMI）患者40例于症状发作后2h、4h、6h、24h测定血浆BNP浓度。AMI患者于症状发作后6h同时测定血清肌钙蛋白含量。结果UA组BNP水平（145.07±78.15）pg/mL明显高于SA组（32.05±7.75）pg/mL，P＜0.01；AMI发病后4h、6h、24h血浆BNP水平（220.15±126.30）pg/mL、（335.83±170.41）pg/mL、（489.90±244.73）pg/mL，均明显高于UA组（145.07±78.15）pg/mL，P＜0.01，且随着症状发作时间的延长而明显增高，P＜0.01。AMI组患者症状发作6h血浆BNP水平与CTnI呈明显正相关，r=0.874，P＜0.01。结论血浆BNP可以作为AMI早期诊断的辅助指标。
目的：分析急性心肌梗死早期血漿腦鈉肽水平的變換情況，為臨床治療積纍經驗。方法選擇穩定型心絞痛（SA）患者、不穩定型心絞痛（UA）患者及健康對照組各20例測定血漿BNP濃度，急性心肌梗死（AMI）患者40例于癥狀髮作後2h、4h、6h、24h測定血漿BNP濃度。AMI患者于癥狀髮作後6h同時測定血清肌鈣蛋白含量。結果UA組BNP水平（145.07±78.15）pg/mL明顯高于SA組（32.05±7.75）pg/mL，P＜0.01；AMI髮病後4h、6h、24h血漿BNP水平（220.15±126.30）pg/mL、（335.83±170.41）pg/mL、（489.90±244.73）pg/mL，均明顯高于UA組（145.07±78.15）pg/mL，P＜0.01，且隨著癥狀髮作時間的延長而明顯增高，P＜0.01。AMI組患者癥狀髮作6h血漿BNP水平與CTnI呈明顯正相關，r=0.874，P＜0.01。結論血漿BNP可以作為AMI早期診斷的輔助指標。
목적：분석급성심기경사조기혈장뇌납태수평적변환정황，위림상치료적루경험。방법선택은정형심교통（SA）환자、불은정형심교통（UA）환자급건강대조조각20례측정혈장BNP농도，급성심기경사（AMI）환자40례우증상발작후2h、4h、6h、24h측정혈장BNP농도。AMI환자우증상발작후6h동시측정혈청기개단백함량。결과UA조BNP수평（145.07±78.15）pg/mL명현고우SA조（32.05±7.75）pg/mL，P＜0.01；AMI발병후4h、6h、24h혈장BNP수평（220.15±126.30）pg/mL、（335.83±170.41）pg/mL、（489.90±244.73）pg/mL，균명현고우UA조（145.07±78.15）pg/mL，P＜0.01，차수착증상발작시간적연장이명현증고，P＜0.01。AMI조환자증상발작6h혈장BNP수평여CTnI정명현정상관，r=0.874，P＜0.01。결론혈장BNP가이작위AMI조기진단적보조지표。
Objective To discuss the dynamic changes and also the clinical signiifcance of BNP in the patients with no cardiac insufifciency after the onset of AMI. Methods Serum BNP of 20 SA cases, 20 UA cases , 20 healthy cases was tested and the serum BNP of 40 AMI cases also be testde in 2h , 4h , 6h, 24h after the onset time. Determine the serum cTnI concentration of AMI patients after 6h of onset. Results BNP level of UA group(145.07±78.15)pg/mL are obviously higher than SA group (32.05±7.75 pg/mL), P<0.01. BNP level in 4h , 6h , 24h after AMI onset(220.15±126.30) pg/mL、(335.83±170.41)pg/mL、(489.90±244.73)pg/mL) are obviously higher than UA group(145.07±78.15)pg/mL, P<0.01, and with the onset time prolonging , BNP level in AMI group is increasing obviously . the BNP level and cTnI are having positive relativity in 6h after the AMI onset, r=0.874 ,P<0.01. Conclusion The serum BNP level may be another biochemistry marker to predict the prognosis of AMI patient.
