CAJ | 학술논문

目的：探讨不同治疗方案对大面积脑梗死（Massive cerebral infarction，MCI）患者神经功能评分的影响与治疗效果。方法回顾性分析41例 MCI 患者，其中15例采用阿替普酶溶栓治疗为研究组；26例采用脱水降颅压、脑保护、稳定斑块等治疗为对照组，并分析年龄、性别、脑卒中危险因素（心房纤颤、高血压、糖尿病）、美国国立卫生研究院卒中量表（NIHSS）评分、格拉斯哥昏迷量表（GCS）评分、改良 Rankin 量表（mRS）评分、并发症等临床资料。结果研究组经溶栓治疗后24h（12.20±5.51和17.95±5.58，t=-3.13，P=0.004）及7d（10.00±5.26和15.00±6.32，t=-2.48，P=0.02）NIHSS 评分均低于对照组，差异有统计学意义。结论严格掌握好溶栓适应症可以改善大面积脑梗死临床神经功能评分。
목적：탐토불동치료방안대대면적뇌경사（Massive cerebral infarction，MCI）환자신경공능평분적영향여치료효과。방법회고성분석41례 MCI 환자，기중15례채용아체보매용전치료위연구조；26례채용탈수강로압、뇌보호、은정반괴등치료위대조조，병분석년령、성별、뇌졸중위험인소（심방섬전、고혈압、당뇨병）、미국국립위생연구원졸중량표（NIHSS）평분、격랍사가혼미량표（GCS）평분、개량 Rankin 량표（mRS）평분、병발증등림상자료。결과연구조경용전치료후24h（12.20±5.51화17.95±5.58，t=-3.13，P=0.004）급7d（10.00±5.26화15.00±6.32，t=-2.48，P=0.02）NIHSS 평분균저우대조조，차이유통계학의의。결론엄격장악호용전괄응증가이개선대면적뇌경사림상신경공능평분。
Objective To explore the influence of intravenous thrombolysis and other therapies in patients with massive cerebral infarction(MCI). Methods Clinical data of 15 patients with acute MCI receiving thrombolytic therapy with alteplase and 26 MCI patients without receiving thrombolytic therapy were retrospectively analyzed. The U.S. National Institutes of Health Stroke Scale(NHISS)and modified Rankin Scale(mRS)were used to identify the extent of neurological function improvement and prognosis of patients at 24 h and 7 days after treatment. Results The significant differences in NIHSS at 24th hour (12.20±5.51vs17.95±5.58, t=-3.13, P=0.004) and 7th day(10.00±5.26 vs15.00±6.32, t=-2.48, P=0.02)were both found between intravenous thrombolysis and control group. Conclusion Strictly grasping the thrombolytic indications of patient with massive cerebral infarction could improve their clinical neurological functions.