中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
34期
22-24
,共3页
慢性阻塞性肺疾病%侵袭性肺部真菌感染%念珠菌病%曲霉菌病%T淋巴细胞%免疫球蛋白
慢性阻塞性肺疾病%侵襲性肺部真菌感染%唸珠菌病%麯黴菌病%T淋巴細胞%免疫毬蛋白
만성조새성폐질병%침습성폐부진균감염%념주균병%곡매균병%T림파세포%면역구단백
Chronic obstructive pulmonary disease%Invasive pulmonary fungal infections%Candidiasis%Aspergillosis%Tlymphocytes%Immunoglobulins
目的：探讨慢性阻塞性肺病（慢阻肺）合并肺部真菌感染患者免疫功能的变化及其意义。方法对2010年1月至2012年12月在徐州市中心医院呼吸科（含呼吸ICU）住院患者中慢性阻塞性肺病（chronic obstructive pulmonary disease，COPD）合并肺部念珠菌感染患者53例及合并肺部曲霉菌感染患者25例作为研究对象，对其免疫功能进行检测，并与20名正常健康人群（健康对照组）进行对比分析。采用流式细胞仪检测周血T淋巴细胞亚群（CD3+CD4+、CD3+CD8+、CD4+/CD8+）的表达率，采用全自动蛋白分析仪检测患者血清IgM、IgG、IgA含量。结果念珠菌组和曲霉菌组的CD3+CD4+百分比及CD4+/CD8+均明显低于健康对照组（P＜0.01），念珠菌组及曲霉菌组CD3+CD8+百分比高于健康对照组（P＜0.05），念珠菌组的CD3+CD4+百分比及CD4+/CD8+均低于曲霉菌组（P＜0.01），而CD3+CD8+百分比在曲霉菌组及念珠菌组之间无统计学差异。与健康对照组比较，念珠菌组和曲霉菌组的IgG明显低于健康对照组，（P＜0.01），IgA均高于健康对照组，（P＜0.05），念珠菌组的IgG高于曲霉菌组（P＜0.01），而念珠菌组及曲霉菌组IgA比较及三组间IgM比较，无统计学差异。结论慢性阻塞性肺病合并肺部念珠菌及曲霉菌感染时，细胞免疫及体液免疫均受损，其中合并曲霉菌感染时的免疫受损状况较合并念珠菌感染时更重。
目的：探討慢性阻塞性肺病（慢阻肺）閤併肺部真菌感染患者免疫功能的變化及其意義。方法對2010年1月至2012年12月在徐州市中心醫院呼吸科（含呼吸ICU）住院患者中慢性阻塞性肺病（chronic obstructive pulmonary disease，COPD）閤併肺部唸珠菌感染患者53例及閤併肺部麯黴菌感染患者25例作為研究對象，對其免疫功能進行檢測，併與20名正常健康人群（健康對照組）進行對比分析。採用流式細胞儀檢測週血T淋巴細胞亞群（CD3+CD4+、CD3+CD8+、CD4+/CD8+）的錶達率，採用全自動蛋白分析儀檢測患者血清IgM、IgG、IgA含量。結果唸珠菌組和麯黴菌組的CD3+CD4+百分比及CD4+/CD8+均明顯低于健康對照組（P＜0.01），唸珠菌組及麯黴菌組CD3+CD8+百分比高于健康對照組（P＜0.05），唸珠菌組的CD3+CD4+百分比及CD4+/CD8+均低于麯黴菌組（P＜0.01），而CD3+CD8+百分比在麯黴菌組及唸珠菌組之間無統計學差異。與健康對照組比較，唸珠菌組和麯黴菌組的IgG明顯低于健康對照組，（P＜0.01），IgA均高于健康對照組，（P＜0.05），唸珠菌組的IgG高于麯黴菌組（P＜0.01），而唸珠菌組及麯黴菌組IgA比較及三組間IgM比較，無統計學差異。結論慢性阻塞性肺病閤併肺部唸珠菌及麯黴菌感染時，細胞免疫及體液免疫均受損，其中閤併麯黴菌感染時的免疫受損狀況較閤併唸珠菌感染時更重。
목적：탐토만성조새성폐병（만조폐）합병폐부진균감염환자면역공능적변화급기의의。방법대2010년1월지2012년12월재서주시중심의원호흡과（함호흡ICU）주원환자중만성조새성폐병（chronic obstructive pulmonary disease，COPD）합병폐부념주균감염환자53례급합병폐부곡매균감염환자25례작위연구대상，대기면역공능진행검측，병여20명정상건강인군（건강대조조）진행대비분석。채용류식세포의검측주혈T림파세포아군（CD3+CD4+、CD3+CD8+、CD4+/CD8+）적표체솔，채용전자동단백분석의검측환자혈청IgM、IgG、IgA함량。결과념주균조화곡매균조적CD3+CD4+백분비급CD4+/CD8+균명현저우건강대조조（P＜0.01），념주균조급곡매균조CD3+CD8+백분비고우건강대조조（P＜0.05），념주균조적CD3+CD4+백분비급CD4+/CD8+균저우곡매균조（P＜0.01），이CD3+CD8+백분비재곡매균조급념주균조지간무통계학차이。여건강대조조비교，념주균조화곡매균조적IgG명현저우건강대조조，（P＜0.01），IgA균고우건강대조조，（P＜0.05），념주균조적IgG고우곡매균조（P＜0.01），이념주균조급곡매균조IgA비교급삼조간IgM비교，무통계학차이。결론만성조새성폐병합병폐부념주균급곡매균감염시，세포면역급체액면역균수손，기중합병곡매균감염시적면역수손상황교합병념주균감염시경중。
Objective To investigate the changes of immune function in patients with invasive pulmonary fungal infections by chronic obstructive pulmonary disease. Methods 78 patients with invasive pulmonary fungal infections by chronic obstructive pulmonary disease were slected, in which ,53 patients were pulmonary candidiasis and 25 patients were pulmonary aspergillosis. The T lymphocyte subsets in peripheral whole blood samples were derected by flow cytometry. The levels of IgM,IgG, IgA were measured by full automatic protein analysis meter. Results The percentages of CD3+CD4+and CD4+/CD8+ratio in candidiasis group and aspergillosis group were lower than those in normal control group(P<0.01). The percentages of CD3+CD8+in candidiasis group and aspergillosis group were higher than those in normal control group(P<0.05). The percentages of CD3+CD4+and CD4+/CCD8+ratio in candidiasis group were lower than those in aspergillosis group(P<0.01).There were no significant differences between candidiasis group and aspergillosis group in the percentages of CD3+CD8+.The levels of IgG in candidiasis group and aspergillosis group were lower than those in normal control group(P<0.01) while the levels of IgA in the two study groups were higher than those in normal control group (P<0.05).The levels of IgG in candidiasis group were higher than those in aspergillosis group(P<0.01).There were no significant differences in the levels of IgA between candidiasis group and aspergillosis group and in the levels of IgM among all there groups. Conclusion The results reveal that both cellular immunity and humoral immunity are impaired in patients with pulmonary candidiasis and pulmonary aspergillosis by COPD. The impairment in patients of pulmonary aspergillosis is more severe than that in patients of pulmonary candidiasis.
