CAJ | 학술논문

目的：探讨肝动脉介入治疗（化疗栓塞术）、射频消融、体外高频热疗法联合治疗原发性肝癌及转移性肝癌的临床疗效及安全性，研究其医学价值，从而为临床提供借鉴意义。方法选取我院2008年10月至2012年12月收治的100例原发性肝癌、转移性肝癌患者，将其随机分为对照组和观察组各50例，对照组采用肝动脉化疗栓塞术治疗，观察组则在栓塞后见实体肿瘤后经皮经肝射频消融联合体外高频热疗法予以治疗。回顾性分析治疗后对其进行 CT 扫描、彩超检查、肿瘤标记物检测、观察记录患者临床副作用等，对治疗效果级安全性作出评估。结果经影像学检查及临床统计，对照组总有效率为92%；观察组经影像学、病理学等检查，并经临床统计后，总有效率为96%，对照组与观察组均未出现严重毒副作用。结论肝动脉化疗栓塞术、射频消融、体外高频热疗法联合治疗肝脏恶性肿瘤安全有效，能更好地改善患者血清 AFP 水平；加大肿瘤坏死效果、减小肿瘤体积；在一定程度上改善了患者的生活质量，值得推广。
목적：탐토간동맥개입치료（화료전새술）、사빈소융、체외고빈열요법연합치료원발성간암급전이성간암적림상료효급안전성，연구기의학개치，종이위림상제공차감의의。방법선취아원2008년10월지2012년12월수치적100례원발성간암、전이성간암환자，장기수궤분위대조조화관찰조각50례，대조조채용간동맥화료전새술치료，관찰조칙재전새후견실체종류후경피경간사빈소융연합체외고빈열요법여이치료。회고성분석치료후대기진행 CT 소묘、채초검사、종류표기물검측、관찰기록환자림상부작용등，대치료효과급안전성작출평고。결과경영상학검사급림상통계，대조조총유효솔위92%；관찰조경영상학、병이학등검사，병경림상통계후，총유효솔위96%，대조조여관찰조균미출현엄중독부작용。결론간동맥화료전새술、사빈소융、체외고빈열요법연합치료간장악성종류안전유효，능경호지개선환자혈청 AFP 수평；가대종류배사효과、감소종류체적；재일정정도상개선료환자적생활질량，치득추엄。
Objective To discuss the clinical effects and safety of primary liver cancer and metastatic liver cancer combined treatment with hepatic arterial chemoembolization、radiofrequency ablation、external high frequency heat therapy, and to research that medical value, so as to offering the reference for clinic. Methods To choose 100 cases of primary liver cancer, metastatic liver cancer patients in the hospital from October in 2008 to December in 2012, and randomly divided into control group and observation group of 50 cases, control group with hepatic artery chemoembolization treatment, observation group with percutaneous transhepatic radiofrequency ablation combined with external high frequency thermotherapy until finding the solid tumor after embolism. After the retrospective analysis treatment, to assess the treat effect and the safety with CT scan, color Doppler ultrasound, testing the tumor marker, observing and recording the patients’ clinical side-effect. Results By imageological examination and clinical statistics, the total effective rate of control group is 92%;by examination of iconography and pathology, and clinical statistics, the total effective rate of observation group is 96%, these two groups haven’t shown the serious toxic and side-effect. Conclusion The treatment of primary liver cancer and metastatic liver cancer combined treatment with hepatic arterial chemoembolization、radiofrequency ablation、external high frequency heat therapy is safe and effective, it can improve the level of AFP of patients’ serum;increase the effect of tumor necrosis、decrease the gross tumor volume; improve the patients’ living quality at some extent, and worth to generalize.