CAJ | 학술논문

小泛素相关修饰物作为一个表达于全身多个器官的蛋白质家族,可对胞内多种转录因子、酶、蛋白质进行翻译后修饰.生理状态下,小泛素相关修饰物与胰岛β细胞的发育、成熟以及胰岛素的分泌密切相关.同时,它通过抑制机体自身免疫反应,减少胰岛β细胞凋亡而减缓1型糖尿病的发生、发展.对此家族蛋白及其修饰过程的深入研究为治疗1型糖尿病提供新的思路.
소범소상관수식물작위일개표체우전신다개기관적단백질가족,가대포내다충전록인자、매、단백질진행번역후수식.생리상태하,소범소상관수식물여이도β세포적발육、성숙이급이도소적분비밀절상관.동시,타통과억제궤체자신면역반응,감소이도β세포조망이감완1형당뇨병적발생、발전.대차가족단백급기수식과정적심입연구위치료1형당뇨병제공신적사로.
Small ubiquitin-related modifier(SUMO),as a family of proteins expressing in various organs of the body,can modify transcription factors,enzymes,proteins in many cells.They affect islet β cell development,maturation,and increase insulin secretion.Meanwhile,they suppress autoimmune responses and reduce islet β cells apoptosis to slow down the development of type 1 diabetes.Further investigations of these proteins and their modification processes provide new insights into type 1 diabetes mellitus.