中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
1期
36-37
,共2页
鼻咽癌%局部晚期%同期放化疗
鼻嚥癌%跼部晚期%同期放化療
비인암%국부만기%동기방화료
Nasopharyngeal carcinoma%Locally advanced%Concurrent chemotherapy
目的：分析放疗与化疗综合治疗局部晚期鼻咽癌临床疗效及安全性。方法将180例鼻咽癌患者随机均分为观察组和对照组，观察组采用同步放化疗和辅助化疗方案治疗，对照组采用单纯放疗方案治疗。结果观察组和对照组3年的局部区域无复发生存率、无远处转移生存率及总生存率分别为88.89%、95.56%、100.0%和71.11%、83.33%、67.78%，两组以上指标比较差异均具有统计学意义。治疗期间，观察组恶心呕吐及白细胞减少症的发生率显著高于对照组；治疗后1年，两组主要毒副反应的发生率无显著性差异。结论采用同期放化疗辅助化疗可显著提高局部晚期鼻咽癌患者的远期生存率，虽然其急性毒性发生率较单纯放疗高，但其远期毒性与单纯放疗相当。
目的：分析放療與化療綜閤治療跼部晚期鼻嚥癌臨床療效及安全性。方法將180例鼻嚥癌患者隨機均分為觀察組和對照組，觀察組採用同步放化療和輔助化療方案治療，對照組採用單純放療方案治療。結果觀察組和對照組3年的跼部區域無複髮生存率、無遠處轉移生存率及總生存率分彆為88.89%、95.56%、100.0%和71.11%、83.33%、67.78%，兩組以上指標比較差異均具有統計學意義。治療期間，觀察組噁心嘔吐及白細胞減少癥的髮生率顯著高于對照組；治療後1年，兩組主要毒副反應的髮生率無顯著性差異。結論採用同期放化療輔助化療可顯著提高跼部晚期鼻嚥癌患者的遠期生存率，雖然其急性毒性髮生率較單純放療高，但其遠期毒性與單純放療相噹。
목적：분석방료여화료종합치료국부만기비인암림상료효급안전성。방법장180례비인암환자수궤균분위관찰조화대조조，관찰조채용동보방화료화보조화료방안치료，대조조채용단순방료방안치료。결과관찰조화대조조3년적국부구역무복발생존솔、무원처전이생존솔급총생존솔분별위88.89%、95.56%、100.0%화71.11%、83.33%、67.78%，량조이상지표비교차이균구유통계학의의。치료기간，관찰조악심구토급백세포감소증적발생솔현저고우대조조；치료후1년，량조주요독부반응적발생솔무현저성차이。결론채용동기방화료보조화료가현저제고국부만기비인암환자적원기생존솔，수연기급성독성발생솔교단순방료고，단기원기독성여단순방료상당。
Objective To analyze and evaluate the efficacy and safety of concurrent chemoradiotherapy and adjuvant chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma. Methods 90 patients with locoregionally advanced nasopharyngeal carcinoma were randomly assigned to observation group and control group, patients of the two group received either concurrent ehemoradiotherapy and adjuvant chemotherapy(CCRT) or radiotherapy alone(RT). Results The 3-years local regionalrecurrent-free, distant metastasis-free, and overall survival rate of observation group and control group had statistical significance. The observation group had significantly more toxicities than the control group, including leucopenia, emesis and mueositls. The late toxieities were similar for both group. Conclusion CCRT is superior to RT alone in increasing the distant survival. Although there is significantly increase in major acute toxicity, but no statistically significant increase in major late toxicity.
