中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2014年
11期
52-53
,共2页
高压氧%白介素-1β(IL-1β)%重型颅脑损伤%白介素-6 (IL-6 )
高壓氧%白介素-1β(IL-1β)%重型顱腦損傷%白介素-6 (IL-6 )
고압양%백개소-1β(IL-1β)%중형로뇌손상%백개소-6 (IL-6 )
Hyperbaric oxygen%Interleukin-1 Beta (IL-1β)%Severe craniocerebral injury%Interleukin-6 (IL-6)
目的：探讨高压氧疗法对重型颅脑损伤患者的治疗效果，以及对患者血清白介素-1β和白介素-6水平的影响及意义。方法随机将我院收治的164例重型颅脑损伤患者分成治疗组和对照组各82例。所有患者在积极手术的同时，给予脱水降颅压、抗炎、营养脑细胞等药物治疗，待其生命体征趋向平稳后，治疗组给予高压氧治疗。分别于治疗的第1、11、21天测定2组静脉血中IL-1β和IL-6水平，同时在第1、14、180天采用格拉斯哥昏迷量表评定状态。结果治疗组第180天GCS评分12.35±3.69，明显高于对照组的9.84±3.42；治疗组IL-1β水平在第11、21天分别为（268.53±18.42）pg/mL、（127.64±17.54）pg/mL ，均低于同期对照组；治疗组和对照组的IL-6水平第11天分别（227.51±18.2l）pg/mL、（287.36±15.48）pg/mL ，第21天分别为（90.78±13.93）pg/mL、（100.32±12.27）pg/mL ，治疗组血清IL-6水平均显著低于同一时间对照组（P＜0.05）。结论高压氧治疗能改善重型颅脑损伤患者的昏迷状态，抑制IL-1β和IL-6的产生和释放，对脑细胞具有保护作用。
目的：探討高壓氧療法對重型顱腦損傷患者的治療效果，以及對患者血清白介素-1β和白介素-6水平的影響及意義。方法隨機將我院收治的164例重型顱腦損傷患者分成治療組和對照組各82例。所有患者在積極手術的同時，給予脫水降顱壓、抗炎、營養腦細胞等藥物治療，待其生命體徵趨嚮平穩後，治療組給予高壓氧治療。分彆于治療的第1、11、21天測定2組靜脈血中IL-1β和IL-6水平，同時在第1、14、180天採用格拉斯哥昏迷量錶評定狀態。結果治療組第180天GCS評分12.35±3.69，明顯高于對照組的9.84±3.42；治療組IL-1β水平在第11、21天分彆為（268.53±18.42）pg/mL、（127.64±17.54）pg/mL ，均低于同期對照組；治療組和對照組的IL-6水平第11天分彆（227.51±18.2l）pg/mL、（287.36±15.48）pg/mL ，第21天分彆為（90.78±13.93）pg/mL、（100.32±12.27）pg/mL ，治療組血清IL-6水平均顯著低于同一時間對照組（P＜0.05）。結論高壓氧治療能改善重型顱腦損傷患者的昏迷狀態，抑製IL-1β和IL-6的產生和釋放，對腦細胞具有保護作用。
목적：탐토고압양요법대중형로뇌손상환자적치료효과，이급대환자혈청백개소-1β화백개소-6수평적영향급의의。방법수궤장아원수치적164례중형로뇌손상환자분성치료조화대조조각82례。소유환자재적겁수술적동시，급여탈수강로압、항염、영양뇌세포등약물치료，대기생명체정추향평은후，치료조급여고압양치료。분별우치료적제1、11、21천측정2조정맥혈중IL-1β화IL-6수평，동시재제1、14、180천채용격랍사가혼미량표평정상태。결과치료조제180천GCS평분12.35±3.69，명현고우대조조적9.84±3.42；치료조IL-1β수평재제11、21천분별위（268.53±18.42）pg/mL、（127.64±17.54）pg/mL ，균저우동기대조조；치료조화대조조적IL-6수평제11천분별（227.51±18.2l）pg/mL、（287.36±15.48）pg/mL ，제21천분별위（90.78±13.93）pg/mL、（100.32±12.27）pg/mL ，치료조혈청IL-6수평균현저저우동일시간대조조（P＜0.05）。결론고압양치료능개선중형로뇌손상환자적혼미상태，억제IL-1β화IL-6적산생화석방，대뇌세포구유보호작용。
Objective To explore the therapeutic effect of hyperbaric oxygen therapy on patients with severe craniocerebral injuries ,and its effect on serum interleukin-1β and interleukin-6 levels. Methods One hundred and sixty-four cases of severe craniocerebral injury patients admitted to the hospital were randomly divided into two groups ,namely ,treatment group and control group ,each with 82 cases. While all patients were actively made operation on ,drugs to lower the intracranial pressure , to achieve anti inflammation ,and to nourish brain cells ,were also given. Not until their vital signs became stable were they treated with hyperbaric oxygen. Then the IL-1βand IL-6 level of venous blood were measured in both groups respectively ,on the 1st ,11th ,and 21st day during the treatment ,simultaneously assessment on the consciousness sate of patients on the 1st , 14th ,180th day using the Glasgow coma scale was made.Results The average GCS score of treatment group on the 180th day was (12.35 ± 3.69) ,significantly higher than (9.84 ± 3.42) of control group ,while its IL-1βlevel on the 11th ,and 21st day respectively accounted for (268.53 ± 18.42) pg/mL ,(127.64 ± 17.54) pg/mL ,lower than those of control group. The IL-6 level of both groups were respectively (227.51 ± 18.2l) pg/mL ,(287.36 ± 15.48) pg/mL on the 11th day ,and (90.78 ± 13.93) pg/mL ,(100.32 ± 12.27) pg/mL on the 21st day ,that is ,the average serum IL-6 level of treatment group was obvi-ously lower than that of control group at the same time(P<0.05).Conclusion Hyperbaric oxygen therapy can improve the co-matose state of patients with severe craniocerebral injuries ,control the producing and releasing of their IL-1βand IL-6 ,and sig-nificantly protect their brain cells.
