CAJ | 학술논문

碳水化合物活性酶数据库（ CAZy）是关于能够合成或者分解复杂碳水化合物和糖复合物的酶类的一个数据库资源，其基于蛋白质结构域中的氨基酸序列相似性，将碳水化合物活性酶类归入不同蛋白质家族。 CAZy数据库中包含了碳水化合物酶类的物种来源、酶功能EC分类、基因序列、蛋白质序列及其结构等信息。而随着宏基因组学技术的快速发展，CAZy数据库中家族内序列数据量剧增，这为家族内进一步进行亚家族分类奠定了基础；而蛋白质家族内新一层精细分类的引入可提高亚家族中酶分子功能预测的准确度，进而可指导酶分子理性设计来提高特定功能酶组分设计的成功概率，从而推动生物质转化产业的发展。
탄수화합물활성매수거고（ CAZy）시관우능구합성혹자분해복잡탄수화합물화당복합물적매류적일개수거고자원，기기우단백질결구역중적안기산서렬상사성，장탄수화합물활성매류귀입불동단백질가족。 CAZy수거고중포함료탄수화합물매류적물충래원、매공능EC분류、기인서렬、단백질서렬급기결구등신식。이수착굉기인조학기술적쾌속발전，CAZy수거고중가족내서렬수거량극증，저위가족내진일보진행아가족분류전정료기출；이단백질가족내신일층정세분류적인입가제고아가족중매분자공능예측적준학도，진이가지도매분자이성설계래제고특정공능매조분설계적성공개솔，종이추동생물질전화산업적발전。
The carbohydrate-active enzyme ( CAZy ) database is a knowledge-based resource specialized in enzymes that synthesis and degrade complex carbohydrates and glycoconjugates.CAZymes were classified into several distinct families based on amino-acid sequence similarity.The information about GenBank accession number,EC designation,family,organism could be accessed in CAZy database and it has been linked with other bioinformatics databases.With the development of metagenomics,the number of sequences in CAZy database increased rapidly,making better opportunity for the refinement of CAZy families into subfamilies.The possibility of function prediction and molecular engineering of CAZymes were improved,thus promoting the rapid development of the conversion of biomass.