中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
36期
1-3
,共3页
疱疹病毒4型,人%传染性单核细胞增多症%T淋巴细胞%免疫球蛋白类
皰疹病毒4型,人%傳染性單覈細胞增多癥%T淋巴細胞%免疫毬蛋白類
포진병독4형,인%전염성단핵세포증다증%T림파세포%면역구단백류
Herpesvirus 4,human%Infectious mononucleosis%T-lymphocytes%Immunoglobulins
目的 探讨EB病毒感染所致的传染性单核细胞增多症(IM)患儿免疫功能状况及其与临床和预后的关系.方法 用免疫放射比浊法检测50例IM患儿(IM组)急性期、恢复期血清免疫球蛋白,用流式细胞术检测外周血T淋巴细胞亚群CD3+、CD4+、CD8+、CD19+、CD23+,同期检测50例同龄健康儿童(对照组).结果 IM组急性期IgA、IgG、IgM分别为(0.75±0.65)、(7.55±2.05)、(1.85±0.55) g/L,IM组恢复期分别为(0.95±0.55)、(8.85±2.25)、(1.75±0.65) g/L,对照组分别为(1.25±0.75)、(10.65±2.55)、(1.80±0.50)g/L,IM组急性期IgA、IgG明显低于IM组恢复期和对照组(P＜0.01),而IgM与IM组恢复期和对照组比较差异无统计学意义(P＞0.05).IM组急性期CD3+、CD4+、CD8+、CD4+/CD8+、CD19+、CD23+分别为0.6050±0.0850、0.2080±0.0315、0.6520±0.0520、0.45±0.35、0.0580±0.0205、0.0250±0.0135,IM组恢复期分别为0.7220±0.0820、0.3575±0.0375、0.3565±0.0565、1.45±0.45、0.1580±0.0280、0.0625±0.0225,对照组分别为0.7530±0.0830、0.4850±0.0450、0.3275±0.0575、1.48±0.55、0.1850±0.0560、0.0805±0.0175,IM组急性期CD3+、CD4+、CD4+/CD8+、CD19+、CD23+明显低于IM组恢复期和对照组(P＜0.05),而CD8+明显高于IM组恢复期和对照组(P＜0.05).结论 EB病毒感染患儿外周血免疫球蛋白、T淋巴细胞亚群明显异常.
目的 探討EB病毒感染所緻的傳染性單覈細胞增多癥(IM)患兒免疫功能狀況及其與臨床和預後的關繫.方法 用免疫放射比濁法檢測50例IM患兒(IM組)急性期、恢複期血清免疫毬蛋白,用流式細胞術檢測外週血T淋巴細胞亞群CD3+、CD4+、CD8+、CD19+、CD23+,同期檢測50例同齡健康兒童(對照組).結果 IM組急性期IgA、IgG、IgM分彆為(0.75±0.65)、(7.55±2.05)、(1.85±0.55) g/L,IM組恢複期分彆為(0.95±0.55)、(8.85±2.25)、(1.75±0.65) g/L,對照組分彆為(1.25±0.75)、(10.65±2.55)、(1.80±0.50)g/L,IM組急性期IgA、IgG明顯低于IM組恢複期和對照組(P＜0.01),而IgM與IM組恢複期和對照組比較差異無統計學意義(P＞0.05).IM組急性期CD3+、CD4+、CD8+、CD4+/CD8+、CD19+、CD23+分彆為0.6050±0.0850、0.2080±0.0315、0.6520±0.0520、0.45±0.35、0.0580±0.0205、0.0250±0.0135,IM組恢複期分彆為0.7220±0.0820、0.3575±0.0375、0.3565±0.0565、1.45±0.45、0.1580±0.0280、0.0625±0.0225,對照組分彆為0.7530±0.0830、0.4850±0.0450、0.3275±0.0575、1.48±0.55、0.1850±0.0560、0.0805±0.0175,IM組急性期CD3+、CD4+、CD4+/CD8+、CD19+、CD23+明顯低于IM組恢複期和對照組(P＜0.05),而CD8+明顯高于IM組恢複期和對照組(P＜0.05).結論 EB病毒感染患兒外週血免疫毬蛋白、T淋巴細胞亞群明顯異常.
목적 탐토EB병독감염소치적전염성단핵세포증다증(IM)환인면역공능상황급기여림상화예후적관계.방법 용면역방사비탁법검측50례IM환인(IM조)급성기、회복기혈청면역구단백,용류식세포술검측외주혈T림파세포아군CD3+、CD4+、CD8+、CD19+、CD23+,동기검측50례동령건강인동(대조조).결과 IM조급성기IgA、IgG、IgM분별위(0.75±0.65)、(7.55±2.05)、(1.85±0.55) g/L,IM조회복기분별위(0.95±0.55)、(8.85±2.25)、(1.75±0.65) g/L,대조조분별위(1.25±0.75)、(10.65±2.55)、(1.80±0.50)g/L,IM조급성기IgA、IgG명현저우IM조회복기화대조조(P＜0.01),이IgM여IM조회복기화대조조비교차이무통계학의의(P＞0.05).IM조급성기CD3+、CD4+、CD8+、CD4+/CD8+、CD19+、CD23+분별위0.6050±0.0850、0.2080±0.0315、0.6520±0.0520、0.45±0.35、0.0580±0.0205、0.0250±0.0135,IM조회복기분별위0.7220±0.0820、0.3575±0.0375、0.3565±0.0565、1.45±0.45、0.1580±0.0280、0.0625±0.0225,대조조분별위0.7530±0.0830、0.4850±0.0450、0.3275±0.0575、1.48±0.55、0.1850±0.0560、0.0805±0.0175,IM조급성기CD3+、CD4+、CD4+/CD8+、CD19+、CD23+명현저우IM조회복기화대조조(P＜0.05),이CD8+명현고우IM조회복기화대조조(P＜0.05).결론 EB병독감염환인외주혈면역구단백、T림파세포아군명현이상.
Objective To study on immunity function in infectious mononucleosis (IM) children infected by Epstein-Barr virus (EBV) and its relationship with clinic and prognosis.Methods Serum immunoglobulin was detected by immunoradiometric nephelometry,expressions of C D3+,CD4+,CD8+,CD19+,CD23+ on T-lymphocytes subset in peripheral blood were measured by flow cytometry in 50 IM (IM group)who was in acute and convalescent period,and compared with 50 healthy controls (control group).Results The levels of IgA,IgG,IgM in IM group with acute period were (0.75 ± 0.65),(7.55 ± 2.05),(1.85 ± 0.55)g/L,in IM group with convalescent period were (0.95 ± 0.55),(8.85 ± 2.25),(1.75 ± 0.65) g/L.In control group,those were (1.25 ± 0.75),(10.65 ± 2.55),(1.80 ± 0.50) g/L.IgA and IgG in IM group with acute period were significantly lower than those in IM group with convalescent period and control group (P ＜0.01),but IgM was no significant difference among them (P ＞0.05).The levels of CD3+,CD4+,CD8+,CD4+/CD8+,CD19+,CD23+ in IM group with acute period were 0.6050 ± 0.0850,0.2080 ± 0.0315,0.6520 ± 0.0520,0.45 ± 0.35,0.0580 ± 0.0205,0.0250 ± 0.0135,in IM group with convalescent period were 0.7220 ± 0.0820,0.3575 ± 0.0375,0.3565 ± 0.0565,1.45 ± 0.45,0.1580 ± 0.0280,0.0625 ± 0.0225.In control group,those were 0.7530 ± 0.0830、0.4850 ± 0.0450、0.3275 ± 0.0575 1.48 ± 0.55、0.1850 ± 0.0560、0.0805 ± 0.0175.CD3+,CD4+,CD4+/CD8+,CD19+,CD23+ in IM group with acute period were significantly lower than those in IM group with convalescent period and control group (P ＜ 0.05),but CD8+ was significantly higher than that in IM group with convalescent period and control group (P ＜0.05).Conclusion The abnormality of immunoglobulin and T-lymphocytes subset in children infected by EBV is obvious.
