世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
1期
32-35
,共4页
康庐琛%谭新%张金赫%刘泽%张亚松%邓伟民
康廬琛%譚新%張金赫%劉澤%張亞鬆%鄧偉民
강려침%담신%장금혁%류택%장아송%산위민
5-羟色胺%骨密度%补肾壮骨冲剂%骨质疏松症
5-羥色胺%骨密度%補腎壯骨遲劑%骨質疏鬆癥
5-간색알%골밀도%보신장골충제%골질소송증
5-HT%Bone Density%Bushen Zhuanggu Granules%Osteoporosis
目的:观察补肾壮骨冲剂对原发性骨质疏松症患者(Osteoporosis,OP)的肠源性5-羟色胺(5-hydroxytryptamine,5-HT)浓度和骨密度的影响,探讨其作用机制。方法:分析60例原发性骨质疏松症患者,在服用补肾壮骨冲剂治疗前后肠源性5-HT浓度的差异。1)本研究所有样本为2011年5月至2012年12月间到广州军区广州总医院住院部及门诊部就诊的确诊为原发性骨质疏松症的患者。2)肠源性5-HT测定:上午8~9点抽取禁食12 h后空腹肘静脉血3 mL,3000 r/min即时离心5 min后,将血清置于-80℃冰箱保存,采用酶联免疫分析法检测5-HT的含量。3)骨密度测定:采用美国GE公司生产的Lunar Prodigy双能X线( DEXA)骨密度仪,检测各部位BMD。4)骨生化指标测定:采用酶联免疫分析法检测血清中肠源性5-HT的含量、电化学发光免疫分析法分析血清P1NP、β-Crosslaps、PTH的含量。结果:治疗半年后血清中的5-HT浓度下降5.20%、PINP浓度下降12.72%、β-Crosslaps下降26.92%、PTH下降5.42%,治疗前后的差异具有统计学意义( P均<0.05,表2);腰椎、左侧股骨颈、Ward’ s三角、大转子和左侧股骨上端的BMD在治疗后分别增加了0.96%,1.67%,2.91%,1.44%和1.29%,与治疗前相比,左侧股骨颈、Ward’s三角和左侧股骨上端处的差异具有统计学意义(P均<0.05,表3)。结论:补肾壮骨冲剂可以通过调节脾肾功能,减低肠源性5-HT浓度,提高骨密度。
目的:觀察補腎壯骨遲劑對原髮性骨質疏鬆癥患者(Osteoporosis,OP)的腸源性5-羥色胺(5-hydroxytryptamine,5-HT)濃度和骨密度的影響,探討其作用機製。方法:分析60例原髮性骨質疏鬆癥患者,在服用補腎壯骨遲劑治療前後腸源性5-HT濃度的差異。1)本研究所有樣本為2011年5月至2012年12月間到廣州軍區廣州總醫院住院部及門診部就診的確診為原髮性骨質疏鬆癥的患者。2)腸源性5-HT測定:上午8~9點抽取禁食12 h後空腹肘靜脈血3 mL,3000 r/min即時離心5 min後,將血清置于-80℃冰箱保存,採用酶聯免疫分析法檢測5-HT的含量。3)骨密度測定:採用美國GE公司生產的Lunar Prodigy雙能X線( DEXA)骨密度儀,檢測各部位BMD。4)骨生化指標測定:採用酶聯免疫分析法檢測血清中腸源性5-HT的含量、電化學髮光免疫分析法分析血清P1NP、β-Crosslaps、PTH的含量。結果:治療半年後血清中的5-HT濃度下降5.20%、PINP濃度下降12.72%、β-Crosslaps下降26.92%、PTH下降5.42%,治療前後的差異具有統計學意義( P均<0.05,錶2);腰椎、左側股骨頸、Ward’ s三角、大轉子和左側股骨上耑的BMD在治療後分彆增加瞭0.96%,1.67%,2.91%,1.44%和1.29%,與治療前相比,左側股骨頸、Ward’s三角和左側股骨上耑處的差異具有統計學意義(P均<0.05,錶3)。結論:補腎壯骨遲劑可以通過調節脾腎功能,減低腸源性5-HT濃度,提高骨密度。
목적:관찰보신장골충제대원발성골질소송증환자(Osteoporosis,OP)적장원성5-간색알(5-hydroxytryptamine,5-HT)농도화골밀도적영향,탐토기작용궤제。방법:분석60례원발성골질소송증환자,재복용보신장골충제치료전후장원성5-HT농도적차이。1)본연구소유양본위2011년5월지2012년12월간도엄주군구엄주총의원주원부급문진부취진적학진위원발성골질소송증적환자。2)장원성5-HT측정:상오8~9점추취금식12 h후공복주정맥혈3 mL,3000 r/min즉시리심5 min후,장혈청치우-80℃빙상보존,채용매련면역분석법검측5-HT적함량。3)골밀도측정:채용미국GE공사생산적Lunar Prodigy쌍능X선( DEXA)골밀도의,검측각부위BMD。4)골생화지표측정:채용매련면역분석법검측혈청중장원성5-HT적함량、전화학발광면역분석법분석혈청P1NP、β-Crosslaps、PTH적함량。결과:치료반년후혈청중적5-HT농도하강5.20%、PINP농도하강12.72%、β-Crosslaps하강26.92%、PTH하강5.42%,치료전후적차이구유통계학의의( P균<0.05,표2);요추、좌측고골경、Ward’ s삼각、대전자화좌측고골상단적BMD재치료후분별증가료0.96%,1.67%,2.91%,1.44%화1.29%,여치료전상비,좌측고골경、Ward’s삼각화좌측고골상단처적차이구유통계학의의(P균<0.05,표3)。결론:보신장골충제가이통과조절비신공능,감저장원성5-HT농도,제고골밀도。
Objective:To analyze the impact of Bushen Zhuanggu Granules on enterogenous 5-hydroxytryptamine and bone density and mechanism of action .Methods:To compare the enterogenous 5-HT levels of 60 osteoporosis patients pre-and post taking Bushen Zhuang-gu Granules.1)All the patients enrolled were diagnosed as osteoporosis , who were in-patients or out-patients of the General Hospital of Guangzhou Command between May 2011 to December 2012.2) Measureing enterogenous 5-HT:drew elbow venous blood 3ml between 8-9 am (fasting), centrifuged at 3000 r/min for 5 minutes at room temperature, and immediately frozen at-80℃.5-HT levels were meas-ured by ELISA.3)Bone density was measured using GE company's Lunar Prodigy dual energy X ray(DEXA)bone density meter.4) Bi-ochemical indices of bone:PINP、β-Crosslaps and PTH levels were measured using electrochemiluminescence immunoassay .Results:Af-ter 6-months of treatment , the 5-HT levels were reduced by 5.20%, the levels of PINP、β-Crosslaps、PTH were respectively reduced by 12.72%、26.92%and 5.42% ( P<0.05); the BMD of lumbar spine L1-L4, femoral neck, wards and troch were increased by 0. 96%、1.67%、2.91%、1.44%and 1.29%(P<0.05).Conclusion:The Bushen Zhuanggu Granules can adjust the spleen and kidney functions , decrease the level of enterogenous 5-HT, and increase bone density .