CAJ | 학술논문

中药复方量效关系研究起步较晚，其理论、方法尚未建立。当病、证、方、药确定后，其方药的“量”是决定“效”的关键因素，并有其最佳的剂量范围。作用复杂的中药复方的量效关系参数可以用剂量阈表述，包括半饱和剂量，或中位剂量（[D]0.5），最佳剂量阈范围（[D]0.8～[D]0.2），剂量阈（[D]0.2）。当病、证、方、药确定后，中药复方药的效仍然是个复杂性问题。中药复方效应有整体效、器官效、分子效等，并有其相应的剂量阈。
중약복방량효관계연구기보교만，기이론、방법상미건립。당병、증、방、약학정후，기방약적“량”시결정“효”적관건인소，병유기최가적제량범위。작용복잡적중약복방적량효관계삼수가이용제량역표술，포괄반포화제량，혹중위제량（[D]0.5），최가제량역범위（[D]0.8～[D]0.2），제량역（[D]0.2）。당병、증、방、약학정후，중약복방약적효잉연시개복잡성문제。중약복방효응유정체효、기관효、분자효등，병유기상응적제량역。
It has not been long since beginning of the research of dose-effect relationship of TCM , therefore the methods and theories have not been established yet .When the disease, syndrome, prescription and herbs are determined , it is the dose of the prescription that decides the efficacy , and that there is the optimal dose range .Dose-effect relationship can be expressed by dose threshold , including Me-dian effective dose, or Medium dose([D]0.5), Optimal dose range([D]0.8 ~[D]0.2), Threshold dose([D]0.2).Even if the disease, syndrome , prescription and herbs are determined , the effect of TCM compound formula remains a complicate issue .There are the global effect, the organism effect, the molecular effect, accordingly there should be corresponding threshold dose ranges .