南通大学学报（医学版）
南通大學學報（醫學版）
남통대학학보（의학판）
JOURNAL OF NANTONG UNIVERSITY(MEDICAL SCIENCES)
2014年
1期
40-42
,共3页
梅毒%苄星青霉素%妊娠梅毒%新生儿存活率%先天梅毒儿发病率%早诊断%早治疗
梅毒%芐星青黴素%妊娠梅毒%新生兒存活率%先天梅毒兒髮病率%早診斷%早治療
매독%변성청매소%임신매독%신생인존활솔%선천매독인발병솔%조진단%조치료
syphilis%Benzathine Benzylpenicilin%pregnancy syphilis%neonates live rate%congenital syphilis incidence rate%early-diagnosis%early-therapy
目的：探讨梅毒患者的血清学诊断和疗效判断。方法：采用梅毒螺旋体凝集试验和快速血浆反应素环状卡片试验(rapid plasma regain test，RPR)对1257例梅毒和98例妊娠梅毒患者进行测试。在苄星青霉素治疗后，1257例梅毒患者使用RPR随访了24个月。98例妊娠梅毒患者中，66例妊娠梅毒患者治疗组和32例未干预对照组进行了新生儿存活率和先天性梅毒儿发病率比较。结果：在1257例梅毒患者青霉素治疗24个月后，455例一期梅毒患者转阴数为387例(85.05％)，589例二期梅毒患者和213例潜伏期患者转阴数分别为539例(91.51％)和102例(47.89％)，一期和二期梅毒患者的转阴数和转阴率之间比较差异无统计学意义(P＞0.05)，一期和二期与潜伏期梅毒患者之间比较差异有统计学意义(均P＜0.05)。98例妊娠梅毒中，66例妊娠梅毒治疗组新生儿存活63例(95.45%)，较之32例未干预对照组13例(40.63%)明显增高(P<0.05)；66例妊娠梅毒治疗组先天性梅毒发生率为13例(19.70%)，较之32例未干预组为22例(68.75%)明显降低(P<0.05)。结论：梅毒患者应早发现，早治疗。苄星青霉素是治疗梅毒的首选药物，妊娠梅毒患者苄星青霉素治疗后可以提高新生儿存活率和降低先天梅毒儿的发生率。
目的：探討梅毒患者的血清學診斷和療效判斷。方法：採用梅毒螺鏇體凝集試驗和快速血漿反應素環狀卡片試驗(rapid plasma regain test，RPR)對1257例梅毒和98例妊娠梅毒患者進行測試。在芐星青黴素治療後，1257例梅毒患者使用RPR隨訪瞭24箇月。98例妊娠梅毒患者中，66例妊娠梅毒患者治療組和32例未榦預對照組進行瞭新生兒存活率和先天性梅毒兒髮病率比較。結果：在1257例梅毒患者青黴素治療24箇月後，455例一期梅毒患者轉陰數為387例(85.05％)，589例二期梅毒患者和213例潛伏期患者轉陰數分彆為539例(91.51％)和102例(47.89％)，一期和二期梅毒患者的轉陰數和轉陰率之間比較差異無統計學意義(P＞0.05)，一期和二期與潛伏期梅毒患者之間比較差異有統計學意義(均P＜0.05)。98例妊娠梅毒中，66例妊娠梅毒治療組新生兒存活63例(95.45%)，較之32例未榦預對照組13例(40.63%)明顯增高(P<0.05)；66例妊娠梅毒治療組先天性梅毒髮生率為13例(19.70%)，較之32例未榦預組為22例(68.75%)明顯降低(P<0.05)。結論：梅毒患者應早髮現，早治療。芐星青黴素是治療梅毒的首選藥物，妊娠梅毒患者芐星青黴素治療後可以提高新生兒存活率和降低先天梅毒兒的髮生率。
목적：탐토매독환자적혈청학진단화료효판단。방법：채용매독라선체응집시험화쾌속혈장반응소배상잡편시험(rapid plasma regain test，RPR)대1257례매독화98례임신매독환자진행측시。재변성청매소치료후，1257례매독환자사용RPR수방료24개월。98례임신매독환자중，66례임신매독환자치료조화32례미간예대조조진행료신생인존활솔화선천성매독인발병솔비교。결과：재1257례매독환자청매소치료24개월후，455례일기매독환자전음수위387례(85.05％)，589례이기매독환자화213례잠복기환자전음수분별위539례(91.51％)화102례(47.89％)，일기화이기매독환자적전음수화전음솔지간비교차이무통계학의의(P＞0.05)，일기화이기여잠복기매독환자지간비교차이유통계학의의(균P＜0.05)。98례임신매독중，66례임신매독치료조신생인존활63례(95.45%)，교지32례미간예대조조13례(40.63%)명현증고(P<0.05)；66례임신매독치료조선천성매독발생솔위13례(19.70%)，교지32례미간예조위22례(68.75%)명현강저(P<0.05)。결론：매독환자응조발현，조치료。변성청매소시치료매독적수선약물，임신매독환자변성청매소치료후가이제고신생인존활솔화강저선천매독인적발생솔。
Objectiv e: To explore the clinical study of serology diagnosis and curative effect test in 1 355 patients with syphilis. Methods:The 1 257 paients with syphilis and 98 patients with pregnancy syphilis were confirmed diagnosis with tre-ponema pallidum particle agglutination test(TPPA) and rapid plasma regain test(RPR). After Benzatihine Benzylpenicilin thera-py, the 1 257 patients with syphilis were followed 24 months by RPR. In 98 patients with pregnancy syphilis, the neonates live rate of the 66 patients with pregnancy syphilis therapy section and 32 pectients with no-interference controls was done compared study;the incidence rate of congenital syphilis infant of the 66 patients with pregnancy syphilis therapy section and the 32 patients with no-interference controls done compared study also. Results: In 1 257 cases confirmed diagnosis general syphilis and after penicillin therapy 12 months, the trans-negative counts(and rate) of the 455 patients with primary syphilis was 387 case(85.05%), but the 589 patients with secondary syphilis and the 213 patients with latent syphilis were 539 cas-es(91.51%) and 102 cases(47.89%) respectively. The trans-negative counts(and rate) of 455 patients with primary syphilis was no significantly difference than those in the 589 patients with secondary syphilis(P>0.05), but the primary and secondary syphilis were significantly higer than those in the 213 patients with latent syphilis(all P<0.05). In 98 patients with pregnan-cy syphilis the neonates live rate(95.45%) in 66 patients with pregnancy syphilis therapy section was significantly higher those in 32 patients with no-interference controls ( 40 . 63%) ( P<0 . 05 ) . The congential syphilis incidence rate in 66 patients with pregnancy syphilis therapy section (19.70%) was significantly lower than those in 32 patients with no-interference con-trols(68.75%)(P<0.05). Conclusion: The syphilis patients should be early-find, early-diagnosis and early-therapy. The Ben-zathine Benzylpenicilin remain the therapy of first choice drug, but may be raised the neonates live rate and decreased con-gential syphilis incidence rate for pregnancy syphilis.
