CAJ | 학술논문

精神分裂症%认知治疗%齐拉西酮%阳性与阴性症状量表%韦氏成人智力量表%韦氏记忆量表%铁槽铁钉测验%手指敲击试验%动作功能测验%手功能协调测验%连线测验测验%威斯康星卡片分类测验%言语流利性测验精神分裂癥%認知治療%齊拉西酮%暘性與陰性癥狀量錶%韋氏成人智力量錶%韋氏記憶量錶%鐵槽鐵釘測驗%手指敲擊試驗%動作功能測驗%手功能協調測驗%連線測驗測驗%威斯康星卡片分類測驗%言語流利性測驗
정신분렬증%인지치료%제랍서동%양성여음성증상량표%위씨성인지역량표%위씨기억량표%철조철정측험%수지고격시험%동작공능측험%수공능협조측험%련선측험측험%위사강성잡편분류측험%언어류리성측험
Schizophrenia%cognitive therapy%ziprasidone%PANSS%WAIS%WMS%INTT%FTT%MFT%HFT%TMTA/B%WCST%VF

目的：探讨认知疗法对首发精神分裂症患者认知功能的影响。方法将100例首发精神分裂症患者随机分为两组。两组均应用齐拉西酮治疗，研究组在此基础上联合认知疗法，观察12周。于治疗前后采用韦氏成人智力量表、韦氏记忆量表、铁槽铁钉测验、手指敲击试验、动作功能测验、手功能测验、连线测验A和B、威斯康星卡片分类测验及言语流利性测验等评定认知状况，采用阳性与阴性症状量表评定精神症状。结果两组治疗8周起铁槽铁钉测验、手指敲击测验、连线测验完成类别数、韦氏成人智力量表和研究组手功能协调测验得分均较治疗前显著改善（ P＜0．05或0．01）；治疗12周末，两组动作功能测验和研究组视觉连线A得分较治疗前显著改善（ P＜0．05或0．01）。研究组治疗4周末起操作智商，治疗12周末铁槽铁钉（左右手）、总记忆商和手指敲击（左手）显著优于对照组（ P＜0．05或0．01）。结论认知治疗能显著改善首发精神分裂症患者的认知功能，效果优于单用药物治疗。
목적：탐토인지요법대수발정신분렬증환자인지공능적영향。방법장100례수발정신분렬증환자수궤분위량조。량조균응용제랍서동치료，연구조재차기출상연합인지요법，관찰12주。우치료전후채용위씨성인지역량표、위씨기억량표、철조철정측험、수지고격시험、동작공능측험、수공능측험、련선측험A화B、위사강성잡편분류측험급언어류리성측험등평정인지상황，채용양성여음성증상량표평정정신증상。결과량조치료8주기철조철정측험、수지고격측험、련선측험완성유별수、위씨성인지역량표화연구조수공능협조측험득분균교치료전현저개선（ P＜0．05혹0．01）；치료12주말，량조동작공능측험화연구조시각련선A득분교치료전현저개선（ P＜0．05혹0．01）。연구조치료4주말기조작지상，치료12주말철조철정（좌우수）、총기억상화수지고격（좌수）현저우우대조조（ P＜0．05혹0．01）。결론인지치료능현저개선수발정신분렬증환자적인지공능，효과우우단용약물치료。
Objective To explore the influences of cognitive therapy on cognitive function of first-episode schizophrenia patient .Methods A total of 100 first-episode schizophrenics were randomly divided into two groups .Both groups were treated with ziprasidone , research group was plus cognitive therapy for 12 weeks .Before and after treatment cognitive status was assessed using the Wechsler Adult Intelligence Scale (WAIS) ,Wechsler Memory Scale (WMS) ,Iron Nails Tank Tests (INTT ) ,Finger Tapping Test (FTT) ,Motor Function Test (MFT) ,Hand Function Test (HFT) ,Tail Making Test A and B (TMTA/B) ,Wisconsin Card Sorting Test (WCST ) and Verbal Fluency Test (VF) and mental symptom with the Positive and Negative Syndrome Scale (PANSS) .Results Since the 8th week treatment the INTT ,FTT , completed sorts of the TM T ,WAIS scores of both groups and hand coordination of research group im-proved more significantly compared with pretreatment (P<0 .05 or 0 .01);at the end of the 12th week the MFT scores of both groups and visual TMTA score of research group improved more significantly com-pared with pretreatment (P<0 .05 or 0 .01) .Performance IQ since the end of the 4th week and INTT (left/right hand) ,total MQ and FTT (right hand) at the end of the 12th week were better in research than con-trol group (P<0 .05 or 0 .01) .Conclusion Cognitive therapy could significantly improve cognitive func-tion of first-episode schizophrenic compared with single pharmacotherapy .