CAJ | 학술논문

目的：探讨彝族人乙醛脱氢酶2基因多态性及其与饮酒习惯的关系。方法采用多聚酶链式反应-限制性长度片段多态性技术测定215名彝族人乙醛脱氢酶2基因多态性，并分析其与饮酒习惯的关系。结果本组中乙醛脱氢酶2基因的 G1951A 位点野生纯合型频率为91．1％、杂合型为6．0％、纯合型为2．8％，等位基因G、A频率分别为94．2％、5．8％；饮酒者和非饮酒者及不同饮酒频度、饮酒量者比较差异均有显著性（ P＜0．05或0．01）。结论彝族人的乙醛脱氢酶2基因具有多态性，其饮酒习惯与乙醛脱氢酶2基因型分布有明显相关性。
목적：탐토이족인을철탈경매2기인다태성급기여음주습관적관계。방법채용다취매련식반응-한제성장도편단다태성기술측정215명이족인을철탈경매2기인다태성，병분석기여음주습관적관계。결과본조중을철탈경매2기인적 G1951A 위점야생순합형빈솔위91．1％、잡합형위6．0％、순합형위2．8％，등위기인G、A빈솔분별위94．2％、5．8％；음주자화비음주자급불동음주빈도、음주량자비교차이균유현저성（ P＜0．05혹0．01）。결론이족인적을철탈경매2기인구유다태성，기음주습관여을철탈경매2기인형분포유명현상관성。
Objective To explore the relationship between polymorphisms of ac-etaldehyde dehydrogenase-2 (ALDH2) gene and drinking habit of Yi peoples in China .Methods Polymorphisms of ALDH2 gene were measured with polymerase chain reaction-restric-tion fragment length polymorphism (PCR-RFLP) techniques and relationships with drinking habits ana-lyzed in 215 Yi peoples in China .Results The distribution frequency of G1951A locus homozygous wild-type of ALDH2 was 91 .1% ,heterozygous type 6 .0% and homozygotic type 2 .8% ,frequencies of allele G and A were respectively 94 .2% and 5 .8% ;there were very significant differences between alcohol users and non-alcohol ones and among ones with different drinking frequencies and capacity for liquor (P<0 .05 or 0 .01) .Conclusion ALDH2s of Yi peoples have polymorphisms ,their drinking habits are related to the distribution of ALDH2 genotype notably .