激光杂志
激光雜誌
격광잡지
LASER JOURNAL
2014年
1期
58-59
,共2页
meta分析%肺癌%miR-21%高表达
meta分析%肺癌%miR-21%高錶達
meta분석%폐암%miR-21%고표체
Meta analysis%lung cancer%miR-21%high expression
目的：评价miR-21的高表达与肺癌预后的相关性。方法：检索PubMed,EMBASE,Google scholar ，维普，CNKI等数据库，收集已公开发表的关于miR-21的高表达与肺癌预后相关性的文献，按meta分析的要求对原始文献的质量进行评估,采用STATA V12.0软件对各研究的效应量进行统计分析。结果：共纳入7篇文献（共369个病例），总生存率(OS)HR的合并值为1.34(95%CI：1.19至1.50，P <0.05)。结论：miR-21的高表达是肺癌预后的一个危险因素。
目的：評價miR-21的高錶達與肺癌預後的相關性。方法：檢索PubMed,EMBASE,Google scholar ，維普，CNKI等數據庫，收集已公開髮錶的關于miR-21的高錶達與肺癌預後相關性的文獻，按meta分析的要求對原始文獻的質量進行評估,採用STATA V12.0軟件對各研究的效應量進行統計分析。結果：共納入7篇文獻（共369箇病例），總生存率(OS)HR的閤併值為1.34(95%CI：1.19至1.50，P <0.05)。結論：miR-21的高錶達是肺癌預後的一箇危險因素。
목적：평개miR-21적고표체여폐암예후적상관성。방법：검색PubMed,EMBASE,Google scholar ，유보，CNKI등수거고，수집이공개발표적관우miR-21적고표체여폐암예후상관성적문헌，안meta분석적요구대원시문헌적질량진행평고,채용STATA V12.0연건대각연구적효응량진행통계분석。결과：공납입7편문헌（공369개병례），총생존솔(OS)HR적합병치위1.34(95%CI：1.19지1.50，P <0.05)。결론：miR-21적고표체시폐암예후적일개위험인소。
Objective To evaluate the correlation between the high expression of miR-21 and the prognosis of lung cancer. Methods:Eligible studies which studied the correlation between the high expression of miR-21 and the prognosis of lung cancer were collected through searching PubMed,EMBASE, and Google scholar , VIP , CNKI databases, etc. A meta analysis method was used to use stata v12.0 software to evaluate whether the high expression of miR-21 has an association with the prognosis of lung cancer. Results:A total of 7 studies (369 cases) were involved in this meta-analysis. For overall survival (OS),the pooled hazard ratio (HR) of higher miR-21 expression in cancerous tissues was 1.34(95%CI: 1.19~1.50 , P<0.05). Conclusions: High expression of miR-21 is a risk factor of lung cancer.
