CAJ | 학술논문

目的：探讨自发性高血压大鼠（SHR）体内高敏C反应蛋白（hsCRP）的来源。方法：在SHR高血压形成过程中，检测血清hsCRP浓度的动态变化，并从蛋白和mRNA水平同时检测主动脉平滑肌和肝脏CRP的表达情况。结果：5周龄后SHR的收缩压随着周龄的增加而增加，其血清hsCRP水平和主动脉平滑肌CRP的表达量进行性增高，但其肝脏CRP却始终为低表达。相关分析显示，SHR的收缩压水平和血清hsCRP浓度呈正相关；主动脉平滑肌CRP的表达量与血清hsCRP浓度也呈正相关；但是肝脏CRP的表达量却与血清hsCRP水平无相关性。结论：SHR高水平的hsCRP主要来源于主动脉平滑肌而不是肝脏。
목적：탐토자발성고혈압대서（SHR）체내고민C반응단백（hsCRP）적래원。방법：재SHR고혈압형성과정중，검측혈청hsCRP농도적동태변화，병종단백화mRNA수평동시검측주동맥평활기화간장CRP적표체정황。결과：5주령후SHR적수축압수착주령적증가이증가，기혈청hsCRP수평화주동맥평활기CRP적표체량진행성증고，단기간장CRP각시종위저표체。상관분석현시，SHR적수축압수평화혈청hsCRP농도정정상관；주동맥평활기CRP적표체량여혈청hsCRP농도야정정상관；단시간장CRP적표체량각여혈청hsCRP수평무상관성。결론：SHR고수평적hsCRP주요래원우주동맥평활기이불시간장。
Objective:To investigate the origin of high sensitive C-reactive protein (hsCRP) in spontaneously hypertensive rats (SHR). Methods:SHRs were used to detect the dynamic changes of their serum hsCRP concentrations. Meanwhile, the CRP expression levels in aortic smooth muscle and liver were also examined both in protein and mRNA during the formation of hypertension. Results:After five weeks old, the systolic pressure of SHR elevated with the increase of week-old. The levels of serum hsCRP and CRP expression in aorta were also increasingly raised, while CRP expressions in liver were low consistently. The analysis of correlation showed that there had positive correlation between the levels of systolic pressure and the concentrations of serum hsCRP, as while as between the levels of CRP expression in aortic smooth muscle and the concentrations of serum hsCRP. However, correlations were not observed between the levels of CPR expression in liver and the serum hsCRP. Conclusion: The elevated hsCRP levels in SHR mainly originate from aortic smooth muscle not from liver.