CAJ | 학술논문

鼻咽癌是我国南方常见的恶性肿瘤之一，5年生存率持续在50%~60%之间，预后较差。血管内皮生长因子属于血小板源生长因子家族，是目前所知唯一特异作用于血管内皮细胞的因子。它非特异性的低表达于人类大部分组织中，但是在大多数肿瘤组织中异常高表达。VEGF与肿瘤的发生、发展、治疗、预后密切相关，是一个具有潜在价值的肿瘤标志物，有望成为肿瘤靶向治疗的理想新靶点。研究发现，VEGF在鼻咽癌组织中同样存在高表达现象，细胞水平利用VEGF基因沉默技术可以抑制鼻咽癌细胞的增殖，因此以VEGF为靶点的治疗方法可能为临床鼻咽癌治疗开辟新途径。本文就VEGF与鼻咽癌的研究现状作一综述。
비인암시아국남방상견적악성종류지일，5년생존솔지속재50%~60%지간，예후교차。혈관내피생장인자속우혈소판원생장인자가족，시목전소지유일특이작용우혈관내피세포적인자。타비특이성적저표체우인류대부분조직중，단시재대다수종류조직중이상고표체。VEGF여종류적발생、발전、치료、예후밀절상관，시일개구유잠재개치적종류표지물，유망성위종류파향치료적이상신파점。연구발현，VEGF재비인암조직중동양존재고표체현상，세포수평이용VEGF기인침묵기술가이억제비인암세포적증식，인차이VEGF위파점적치료방법가능위림상비인암치료개벽신도경。본문취VEGF여비인암적연구현상작일종술。
Nasopharyngeal carcinoma is one of the common malignant tumor in southern China,that 5-year survival rate is in the range of 50%-60%and the prognosis is poor. Vascular endothelial growth factor(VEGF)belongs to the family of platelet-derived growth factors and so far as the only known specific factor acts to vascular endothelial cells. It expresses lower in most tissues of the human with nonspecific manner and higher abnormally in most tumor tissues. The fact that it is related closely to tumor’s occurrence,development,treatment and prognosis suggests that VEGF is a potentially valuable tumor marker and also expected to become an ideal new target for targeted cancer therapy. Some studies found that the phenomenon of high expression of VEGF is also occurs in nasopharyngeal carcinoma and gene silence with VEGF siRNA can inhibit the proliferation of nasopharyngeal carcinoma cell lines. Hence,the treatment using VEGF as the target may open new avenues for the clinical treatment of nasopharyngeal carcinoma. In this paper,it is reviewed about the research status of VEGF and nasopharyngeal carcinoma.