中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
2期
63-64
,共2页
氨氯地平%厄贝沙坦%原发性高血压
氨氯地平%阨貝沙坦%原髮性高血壓
안록지평%액패사탄%원발성고혈압
Amlodipine%Irbesartan%Hypertension
目的：探讨氨氯地平配伍厄贝沙坦治疗原发性高血压的临床疗效。方法：选择2012年1-12月诊断为原发性高血压的门诊及住院患者90例，按随机数字表法分为观察组和对照组各45例，对照组应用氨氯地平片；观察组在此治疗基础上配伍应用厄贝沙坦片。以治疗过程中血压值及常规检查项目作为治疗效果检测指标。结果：2个疗程结束后，两组患者收缩压与舒张压相比治疗前均有下降，观察组血压下降幅度与对照组比较差异有统计学意义（P<0.05）。观察组总有效率93.3%，对照组总有效率73.3%，两组总有效率比较差异有统计学意义（P<0.05）。观察组有3例出现头晕、头痛、面部潮红不良反应，对照组出现2例类似不良反应，两组比较差异无统计学意义（X2=0.21，P>0.05）。肝肾功能、生化指标及心电图改变两组均未有异常。结论：氨氯地平配伍厄贝沙坦治疗原发性高血压患者，降压效果较好，且使用安全，稳定持久，故在考虑降压药物时可以将此作为首选治疗方案。
目的：探討氨氯地平配伍阨貝沙坦治療原髮性高血壓的臨床療效。方法：選擇2012年1-12月診斷為原髮性高血壓的門診及住院患者90例，按隨機數字錶法分為觀察組和對照組各45例，對照組應用氨氯地平片；觀察組在此治療基礎上配伍應用阨貝沙坦片。以治療過程中血壓值及常規檢查項目作為治療效果檢測指標。結果：2箇療程結束後，兩組患者收縮壓與舒張壓相比治療前均有下降，觀察組血壓下降幅度與對照組比較差異有統計學意義（P<0.05）。觀察組總有效率93.3%，對照組總有效率73.3%，兩組總有效率比較差異有統計學意義（P<0.05）。觀察組有3例齣現頭暈、頭痛、麵部潮紅不良反應，對照組齣現2例類似不良反應，兩組比較差異無統計學意義（X2=0.21，P>0.05）。肝腎功能、生化指標及心電圖改變兩組均未有異常。結論：氨氯地平配伍阨貝沙坦治療原髮性高血壓患者，降壓效果較好，且使用安全，穩定持久，故在攷慮降壓藥物時可以將此作為首選治療方案。
목적：탐토안록지평배오액패사탄치료원발성고혈압적림상료효。방법：선택2012년1-12월진단위원발성고혈압적문진급주원환자90례，안수궤수자표법분위관찰조화대조조각45례，대조조응용안록지평편；관찰조재차치료기출상배오응용액패사탄편。이치료과정중혈압치급상규검사항목작위치료효과검측지표。결과：2개료정결속후，량조환자수축압여서장압상비치료전균유하강，관찰조혈압하강폭도여대조조비교차이유통계학의의（P<0.05）。관찰조총유효솔93.3%，대조조총유효솔73.3%，량조총유효솔비교차이유통계학의의（P<0.05）。관찰조유3례출현두훈、두통、면부조홍불량반응，대조조출현2례유사불량반응，량조비교차이무통계학의의（X2=0.21，P>0.05）。간신공능、생화지표급심전도개변량조균미유이상。결론：안록지평배오액패사탄치료원발성고혈압환자，강압효과교호，차사용안전，은정지구，고재고필강압약물시가이장차작위수선치료방안。
Objective:To explore the clinical efficacy of amlodipine combined irbesartan in treatment of hypertension. Method:90 patients who were diagnosed hypertension outpatients or inpatient were chosen in our hospital from Jan 2012 to Dec 2012,and randomly divided into observation group and control group,each of 45 cases. The control group were given amlodipine and the observation group were given irbesartan besides amlodipine.Blood pressure values and routine examination and treatment effect were regared as detection index after two courses of treatment.Result:After two courses, systolic and diastolic blood pressure of two groups were decreased. Compared to the control group,the observation group had significant decrease in blood pressure difference(P<0.05).The total effective rate of observation group was 93.3%,and the control group was 73.3%,total effective rate difference was significant(P<0.05).Three cases had dizziness,headache,facial flushing adverse reactions in the observation group,2 cases had adverse reactions in the control group,the difference was not statistically significant(X2=0.21,P>0.05).Conclusion:Antihypertensive effect of amlodipine combined irbesartan is good in treatment of hypertension,and it is safe,stable and lasting,so it is considered as the first-choice drug of antihypertensive treatment.
