中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
2期
31-32,33
,共3页
地塞米松%甘露醇%脑血管病%脑保护
地塞米鬆%甘露醇%腦血管病%腦保護
지새미송%감로순%뇌혈관병%뇌보호
Dexamethasone%Mannitol%Cerebral vascular disease%Cerebral protection
目的：探讨地塞米松（DXM）和甘露醇合用对急性重症脑血管病脑保护作用的疗效。方法：将160例患者随机分为治疗组和对照组，每组80例。对照组只行常规治疗，治疗组在对照组基础上给予DXM、甘露醇联用治疗，比较两组疗效及并发症情况。结果：治疗后，治疗组ICP恢复正常时间较对照组显著缩短，但两组并发症及急性期病死率比较差异均无统计学意义（P>0.05）；治疗组重症病例存活超过40 d例数（73例）显著高于对照组（34例），两组比较差异有统计学意义（P<0.05）。结论：在脑血管病中，DXM和甘露醇合用对减轻脑水肿、降低颅内压脑保护作用更强，且不增加其并发症和病死率。
目的：探討地塞米鬆（DXM）和甘露醇閤用對急性重癥腦血管病腦保護作用的療效。方法：將160例患者隨機分為治療組和對照組，每組80例。對照組隻行常規治療，治療組在對照組基礎上給予DXM、甘露醇聯用治療，比較兩組療效及併髮癥情況。結果：治療後，治療組ICP恢複正常時間較對照組顯著縮短，但兩組併髮癥及急性期病死率比較差異均無統計學意義（P>0.05）；治療組重癥病例存活超過40 d例數（73例）顯著高于對照組（34例），兩組比較差異有統計學意義（P<0.05）。結論：在腦血管病中，DXM和甘露醇閤用對減輕腦水腫、降低顱內壓腦保護作用更彊，且不增加其併髮癥和病死率。
목적：탐토지새미송（DXM）화감로순합용대급성중증뇌혈관병뇌보호작용적료효。방법：장160례환자수궤분위치료조화대조조，매조80례。대조조지행상규치료，치료조재대조조기출상급여DXM、감로순련용치료，비교량조료효급병발증정황。결과：치료후，치료조ICP회복정상시간교대조조현저축단，단량조병발증급급성기병사솔비교차이균무통계학의의（P>0.05）；치료조중증병례존활초과40 d례수（73례）현저고우대조조（34례），량조비교차이유통계학의의（P<0.05）。결론：재뇌혈관병중，DXM화감로순합용대감경뇌수종、강저로내압뇌보호작용경강，차불증가기병발증화병사솔。
Objective:To investigate the therapeutic effect of combination therapy with dexamethasone(DXM)and mannitol on acute severe cerebrovascular disease cerebral protective effect. Method:One hundred and sixty patients were randomly divided into the treatment group and the control group,the control group only received routine treatment with combination therapy,the treatment group was given DXM and mannitol on the basis of the control group. The indicators between the two groups were compared after treatment,such as the effective rate,complication. Result:ICP recovery time of the treatment group was significantly shorter than that of the control group after the treatment,but the difference of complications and mortality rate between the two groups in acute stage were no statistically significant(P>0.05). The patients survived more than forty days of the control group was 34 cases while the treatment group was 73 cases after treatment,and the difference between the two groups were statistically significant(P<0.05). Conclusion:DXM and mannitol is stronger in reducing brain edema,decreasing intracranial pressure cerebral protective effect in cerebrovascular disease,and does not increase the incidence of complication and mortality.
