中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
2期
19-20,21
,共3页
糖尿病肾病%NAG%Cys-C%蛋白尿%RBP
糖尿病腎病%NAG%Cys-C%蛋白尿%RBP
당뇨병신병%NAG%Cys-C%단백뇨%RBP
Diabetic nephropathy%NAG%Cys-C%Proteinuria%RBP
目的：研究尿内皮素（ET-1）、胱抑素C（Cys-C）、视黄醇结合蛋白（RBP）和NAG酶（NAG）检测在2型糖尿病肾病早期的诊断价值。方法：选取本院2010年1月-2012年12月收治的88例糖尿病患者，根据尿白蛋白排泄率（UAER）的测定结果将其分为无白蛋白尿组、微量白蛋白尿组和临床白蛋白尿组，选取同期门诊的30例健康体检者作为对照组，比较4组间ET-1、Cys-C、RBP和NAG的水平变化。结果：糖尿病肾病组患者ET-1、Cys-C、RBP和NAG水平明显升高（P<0.05），且微量白蛋白尿组和临床白蛋白尿组各项指标均明显高于无蛋白尿组，比较差异有统计学意义（P<0.05）；临床白蛋白尿组的各项指标阳性检出率最高，分别为ET-186.2%、Cys-C 79.3%、RBP 89.7%和NAG 93.1%，阳性检出率的升高与蛋白尿的排泄增多有一定的相关性。结论：ET-1、Cys-C、RBP和NAG在2型糖尿病肾病患者的早期诊断中有较高的阳性检出率，可作为糖尿病肾病的早期诊断依据。
目的：研究尿內皮素（ET-1）、胱抑素C（Cys-C）、視黃醇結閤蛋白（RBP）和NAG酶（NAG）檢測在2型糖尿病腎病早期的診斷價值。方法：選取本院2010年1月-2012年12月收治的88例糖尿病患者，根據尿白蛋白排洩率（UAER）的測定結果將其分為無白蛋白尿組、微量白蛋白尿組和臨床白蛋白尿組，選取同期門診的30例健康體檢者作為對照組，比較4組間ET-1、Cys-C、RBP和NAG的水平變化。結果：糖尿病腎病組患者ET-1、Cys-C、RBP和NAG水平明顯升高（P<0.05），且微量白蛋白尿組和臨床白蛋白尿組各項指標均明顯高于無蛋白尿組，比較差異有統計學意義（P<0.05）；臨床白蛋白尿組的各項指標暘性檢齣率最高，分彆為ET-186.2%、Cys-C 79.3%、RBP 89.7%和NAG 93.1%，暘性檢齣率的升高與蛋白尿的排洩增多有一定的相關性。結論：ET-1、Cys-C、RBP和NAG在2型糖尿病腎病患者的早期診斷中有較高的暘性檢齣率，可作為糖尿病腎病的早期診斷依據。
목적：연구뇨내피소（ET-1）、광억소C（Cys-C）、시황순결합단백（RBP）화NAG매（NAG）검측재2형당뇨병신병조기적진단개치。방법：선취본원2010년1월-2012년12월수치적88례당뇨병환자，근거뇨백단백배설솔（UAER）적측정결과장기분위무백단백뇨조、미량백단백뇨조화림상백단백뇨조，선취동기문진적30례건강체검자작위대조조，비교4조간ET-1、Cys-C、RBP화NAG적수평변화。결과：당뇨병신병조환자ET-1、Cys-C、RBP화NAG수평명현승고（P<0.05），차미량백단백뇨조화림상백단백뇨조각항지표균명현고우무단백뇨조，비교차이유통계학의의（P<0.05）；림상백단백뇨조적각항지표양성검출솔최고，분별위ET-186.2%、Cys-C 79.3%、RBP 89.7%화NAG 93.1%，양성검출솔적승고여단백뇨적배설증다유일정적상관성。결론：ET-1、Cys-C、RBP화NAG재2형당뇨병신병환자적조기진단중유교고적양성검출솔，가작위당뇨병신병적조기진단의거。
Objective:To evaluate the ET-1,Cys-C,RBP and NAG of early diagnosis in patients with type 2 diabetic nephropathy. Method:88 patients with diabetes were selected in our hospital from January 2010 to December 2012,they were divided into non albuminuria group, microalbuminuria group and clinical albuminuria group according to urinary albumin excretion rate(UAER),30 health physical examination patients were selected as control group,the changes of ET-1,Cys-C,RBP and NAG were measured and compared in four groups.Result:ET-1,Cys-C,RBP and NAG of patients with diabetic nephropathy group were significantly increased(P<0.05),and the indicators of microalbuminuria group and clinical albuminuria group were significantly higher than those in without proteinuria group,the differences were statistically significant(P<0.05);Clinical albuminuria group had the highest positive rate contained ET-1 86.2%,Cys-C 79.3%,RBP 89.7%and NAG 93.1%respectively,and increase of positive rate had certain correlation with the excretion of proteinuria.Conclusion:The ET-1,Cys-C,RBP and NAG are higher in the early diagnosis of type 2 diabetic nephropathy patients in positive detection rate,can be used as a basis of diabetic nephropathy for early diagnosis.
