CAJ | 학술논문

目的：探讨单纯性颅脑外伤患者血清中白细胞介素-6(IL-6)、血管紧张素Ⅱ(AngII)的动态变化及其临床意义。方法：将51例单纯性颅脑损伤患者根据GCS评分标准划分中度(M组)、重度（S组）。对照组（C组）来自健康体检者。分别于入院后即刻(0h)、12h、24h、3d、7d 采集M、S组患者血样，测定血清中AnglI、IL-6水平。结果：M组患者血清中AnglI检测值伤后12h内上升达高峰，并在高水平维持，随后逐渐下降，7天后恢复到低水平；S组患者伤后高峰后，高水平维持到入院后1天，至第7天时总体下降至低水平，其各时点血清中AngII水平高于M组及C组，差异有统计学意义(P<0．05)。M组、S组血清IL-6检测值皆于伤后即达高峰。M组随后逐步下降，7天后恢复至低水平。S组伤后3天内一直处于较高水平,7天后恢复至低水平。两组各时点血清IL-6检测值比较及与C组比较差异有统计学意义。住院期间，死亡组与存活组患者入院时AngII、IL-6检测值差异有统计学意义。结论：Ang II、IL-6参与了单纯性脑损伤患者的炎症反应，监测其变化有助于指导临床诊疗及临床预后的判断。
목적：탐토단순성로뇌외상환자혈청중백세포개소-6(IL-6)、혈관긴장소Ⅱ(AngII)적동태변화급기림상의의。방법：장51례단순성로뇌손상환자근거GCS평분표준화분중도(M조)、중도（S조）。대조조（C조）래자건강체검자。분별우입원후즉각(0h)、12h、24h、3d、7d 채집M、S조환자혈양，측정혈청중AnglI、IL-6수평。결과：M조환자혈청중AnglI검측치상후12h내상승체고봉，병재고수평유지，수후축점하강，7천후회복도저수평；S조환자상후고봉후，고수평유지도입원후1천，지제7천시총체하강지저수평，기각시점혈청중AngII수평고우M조급C조，차이유통계학의의(P<0．05)。M조、S조혈청IL-6검측치개우상후즉체고봉。M조수후축보하강，7천후회복지저수평。S조상후3천내일직처우교고수평,7천후회복지저수평。량조각시점혈청IL-6검측치비교급여C조비교차이유통계학의의。주원기간，사망조여존활조환자입원시AngII、IL-6검측치차이유통계학의의。결론：Ang II、IL-6삼여료단순성뇌손상환자적염증반응，감측기변화유조우지도림상진료급림상예후적판단。
Objective:To investigate the clinical values of the dynamic changes of angiotensin 1I(Ang-II)and interleukin-6(IL-6)in the patients with isolated traumatic brain injury(iTBI). Method:51 cases of patients were divided into M group(8<GCS<13)and S group(GCS≤8) according to the GCS scores and 20 cases of healthy people were used as C group.The concentrations of serum Ang-II and IL-6 were determined by immune nephelometry on 0h、12h、24h、3d、7d after the injury.Results:After iTBI, serum Ang-II .IL-6 in the patients peaked in 12h and decreased gradual y thereafter.It was substantial y higher than that of healthy controls group during the 7 day period (P<0.05). Serum values of Ang-II.IL-6 on the admission in the patient alive group was higher than those death group(P<0.05). Conclusions:The concentrations of Ang-II and IL-6 were related to the severity of patients isolated traumatic brain injury.and dynamic observation of Ang-II and IL-6 changes may be used to judge the severity and prognosis in the patients with isolated traumatic brain injury.