医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
2期
51-51,52
,共2页
周俊立%叶小华%邹志辉%蔡旭玲%冼雪珍%汪保国
週俊立%葉小華%鄒誌輝%蔡旭玲%冼雪珍%汪保國
주준립%협소화%추지휘%채욱령%승설진%왕보국
香鳞毛蕨提取物%红色毛癣菌%角鲨烯环氧化酶%β-(1,3)-D-葡聚糖合成酶
香鱗毛蕨提取物%紅色毛癬菌%角鯊烯環氧化酶%β-(1,3)-D-葡聚糖閤成酶
향린모궐제취물%홍색모선균%각사희배양화매%β-(1,3)-D-포취당합성매
Extract of Dryopteris fragrans(L.)Schot%Trichophyton rubrum%Squalene epoxidase%β-(1,3)-D-glucan synthase
目的:研究香鳞毛蕨醇提取物对红色毛癣菌角鲨烯环氧化酶和β-(1,3)-D-葡聚糖合成酶的抑制作用,初步探讨其抗真菌作用机制。方法采用 ELISA测定角鲨烯环氧化酶活性,还原糖法测定β-(1,3)-D-葡聚糖合成酶活性。结果香鳞毛蕨提取物不同浓度组均能降低红色毛癣菌角鲨烯环氧化酶的活性,差异有统计学意义(P<0.05),随香鳞毛蕨提取物浓度增加,红色毛癣菌角鲨烯环氧化酶的活性逐渐降低,香鳞毛蕨提取物中浓度组和高浓度组能降低β-(1,3)-D-葡聚糖合成酶活性,差异有统计学意义(P=0.002,P=0.000)。结论香鳞毛蕨提取物抗真菌作用机制可能和角鲨烯环氧化酶和β-(1,3)-D-葡聚糖合成酶活性受到抑制有关。
目的:研究香鱗毛蕨醇提取物對紅色毛癬菌角鯊烯環氧化酶和β-(1,3)-D-葡聚糖閤成酶的抑製作用,初步探討其抗真菌作用機製。方法採用 ELISA測定角鯊烯環氧化酶活性,還原糖法測定β-(1,3)-D-葡聚糖閤成酶活性。結果香鱗毛蕨提取物不同濃度組均能降低紅色毛癬菌角鯊烯環氧化酶的活性,差異有統計學意義(P<0.05),隨香鱗毛蕨提取物濃度增加,紅色毛癬菌角鯊烯環氧化酶的活性逐漸降低,香鱗毛蕨提取物中濃度組和高濃度組能降低β-(1,3)-D-葡聚糖閤成酶活性,差異有統計學意義(P=0.002,P=0.000)。結論香鱗毛蕨提取物抗真菌作用機製可能和角鯊烯環氧化酶和β-(1,3)-D-葡聚糖閤成酶活性受到抑製有關。
목적:연구향린모궐순제취물대홍색모선균각사희배양화매화β-(1,3)-D-포취당합성매적억제작용,초보탐토기항진균작용궤제。방법채용 ELISA측정각사희배양화매활성,환원당법측정β-(1,3)-D-포취당합성매활성。결과향린모궐제취물불동농도조균능강저홍색모선균각사희배양화매적활성,차이유통계학의의(P<0.05),수향린모궐제취물농도증가,홍색모선균각사희배양화매적활성축점강저,향린모궐제취물중농도조화고농도조능강저β-(1,3)-D-포취당합성매활성,차이유통계학의의(P=0.002,P=0.000)。결론향린모궐제취물항진균작용궤제가능화각사희배양화매화β-(1,3)-D-포취당합성매활성수도억제유관。
Objective To study the inbibitional ef ect of alcohol extract of Dryopteris fragrans ( L.) Schot on squalene epoxidase and β- (1,3) - D - glucan synthase of Trichophyton rubrum and its antifungal mechanism. Methods Determination of squalene epoxidase activity by ELISA test,determination of β- (1,3) - D - glucan synthase activity by method of reducing sugar. Results Extract of Dryopteris fragrans(L.) Schot in dif erent concentration can reduce Trichophyton rubrum squalene epoxidase activity (with statistical significance,P<0.05),with the increasing concentration of the extract of Dryopteris fragrans (L.) Schot ,Trichophyton rubrum squalene epoxidase activity gradual y reduced,the extraction of Dryopteris fragrans(L.) Schot medium concentration group and high concentration group can decreaseβ-(1,3)-D-glucan synthase activity (statistical y significant dif erence,P=0.002,P=0.000). Conclusion The antifungal mechanism of extract of Dryopteris fragrans ( L. ) Schot may be relate to its inhibition on squalene epoxidase andβ-(1,3)-D-glucan synthase activity.