CAJ | 학술논문

目的：研究脑室内注射抗生素治疗高血压脑出血术后颅内感染的临床疗效，以期为临床治疗提供一定的参考意见。方法选取2011-01-2013-01入院诊治的高血压脑出血行开颅手术后颅内感染的患者80例，均行脑室内注射抗生素以治疗感染，观察患者的治疗效果，并对比患者治疗前后的格拉斯哥评分及生活质量情况。结果80例患者中治愈70例，治愈率87.50％；死亡5例，病死率6.25％；平均住院时间（31.2±7.4）d。治疗前轻度昏迷0例，中度昏迷12例，重度昏迷32例，低于3分的重度昏迷36例；治疗后轻度昏迷17例，中度昏迷23例，重度昏迷21例，低于3分的重度昏迷下降到19例；治疗前后差异显著（ P＜0.05）。与治疗前相比，患者在总体健康、积极感受、日常生活能力方面均有显著提高，并且在疼痛与不适、对药物及医疗手段的依赖性方面显著下降；治疗前后差异显著（ P＜0.05）。结论脑室内注射抗生素可有效治疗高血压脑出血术后颅内感染，并提高患者的生活质量、降低昏迷程度；围手术期应加强颅内感染的预防，同时加强对颅内感染患者的相关护理工作。
목적：연구뇌실내주사항생소치료고혈압뇌출혈술후로내감염적림상료효，이기위림상치료제공일정적삼고의견。방법선취2011-01-2013-01입원진치적고혈압뇌출혈행개로수술후로내감염적환자80례，균행뇌실내주사항생소이치료감염，관찰환자적치료효과，병대비환자치료전후적격랍사가평분급생활질량정황。결과80례환자중치유70례，치유솔87.50％；사망5례，병사솔6.25％；평균주원시간（31.2±7.4）d。치료전경도혼미0례，중도혼미12례，중도혼미32례，저우3분적중도혼미36례；치료후경도혼미17례，중도혼미23례，중도혼미21례，저우3분적중도혼미하강도19례；치료전후차이현저（ P＜0.05）。여치료전상비，환자재총체건강、적겁감수、일상생활능력방면균유현저제고，병차재동통여불괄、대약물급의료수단적의뢰성방면현저하강；치료전후차이현저（ P＜0.05）。결론뇌실내주사항생소가유효치료고혈압뇌출혈술후로내감염，병제고환자적생활질량、강저혼미정도；위수술기응가강로내감염적예방，동시가강대로내감염환자적상관호리공작。
Objective To study the clinical efficacy of intraventricular administration of antibiotics for intracranial infection secondary to cranial surgery for hypertensive cerebral hemorrhage ,and to provide reference for clinical treatment.Methods Eighty patients with intracranial infection following cranial surgery for hypertensive cerebral hemorrhage from January 2011-January 2013 admitted to our hospital were performed intraventricular administration of antibiotics to treat the infection ,the ef-ficacy was observed ,Hougesila scores of patients before and after treatment and quality of their life were compared. Results Seventy cases of the 80 patients were cured ,the cure rate was 87.50% ;5 deaths ,mortality rate 6.25% ;the mean hospital stay was 31.2 ± 7.4 days. Before treatment ,mild coma 0 cases ,moderate coma 12 cases ,32 cases of severe coma ,Patients with severe coma less than 3 scores were up to 36 cases ;after treatment ,patients with mild coma was 17 cases ,moderate coma 23 cases ,21 cases of severe coma ,Patients with severe coma less than 3 scores dropped to 19 cases;the difference before and after treatment was significant (P<0.05).Compared with those before treatment ,patients in the general health ,positive feel-ings ,capacity of daily living had been significantly improved ;the pain and discomfort ,the dependence on drug and medical in-struments all decreased significantly ;the difference before and after treatment was significant (P< 0.05).Conclusion intra-ventricular injection of antibiotics is effective in the treatment of intracranial infections secondary to surgery for hypertensive cerebral hemorrhage and can improve patients’ quality of life ,reduce the degree of coma ;the prevention from perioperative in-tracranial infection should be strengthened ,while strengthening care for patients with intracranial infection should be per-formed.