中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
16期
2443-2445
,共3页
妊娠%肝内胆汁淤积症%结局
妊娠%肝內膽汁淤積癥%結跼
임신%간내담즙어적증%결국
Pregnancy%Intrahepatic cholestasis%Outcome
目的 探讨妊娠期肝内胆汁淤积症对妊娠结局的影响.方法 70例确诊为肝内胆汁淤积症的妊娠期妇女设为研究组,选取同一时期70例健康妊娠妇女设为对照组.对两组妊娠期妇女的妊娠结局进行比较.结果 (1)研究组孕产妇血清胆汁酸、谷氨酸氨基转移酶、天冬氨酸氨基转移酶水平分别为(65.61±13.5) μmol/L、(134.31±24.7) U/L、(97.35±21.54) U/L,均高于对照组的(3.34±0.41) μmol/L、(36.16±4.15) U/L、(23.34±4.45) U/L,差异具有统计学意义(P＜0.01)；(2)研究组孕产妇妊娠期高血压疾病发病率为21.42％,胎膜早破发生率为17.14％,产后出血发生率为15.71％,显著高于对照组的7.14％、5.71％、4.29％,差异具有统计学意义(P＜0.05)；(3)研究组新生儿窒息发生率为27.14％,羊水污染发生率为35.71％,宫内窘迫发生率为22.86％,低体重儿所占比例为30.00％,与对照组相比,均显著升高,差异具有统计学意义(P＜0.01).结论 妊娠期肝内胆汁淤积症可以增加围生期并发症的发生率,严重影响胎儿的预后,加强对妊娠期肝内胆汁淤积症的监测具有重要临床意义.
目的 探討妊娠期肝內膽汁淤積癥對妊娠結跼的影響.方法 70例確診為肝內膽汁淤積癥的妊娠期婦女設為研究組,選取同一時期70例健康妊娠婦女設為對照組.對兩組妊娠期婦女的妊娠結跼進行比較.結果 (1)研究組孕產婦血清膽汁痠、穀氨痠氨基轉移酶、天鼕氨痠氨基轉移酶水平分彆為(65.61±13.5) μmol/L、(134.31±24.7) U/L、(97.35±21.54) U/L,均高于對照組的(3.34±0.41) μmol/L、(36.16±4.15) U/L、(23.34±4.45) U/L,差異具有統計學意義(P＜0.01)；(2)研究組孕產婦妊娠期高血壓疾病髮病率為21.42％,胎膜早破髮生率為17.14％,產後齣血髮生率為15.71％,顯著高于對照組的7.14％、5.71％、4.29％,差異具有統計學意義(P＜0.05)；(3)研究組新生兒窒息髮生率為27.14％,羊水汙染髮生率為35.71％,宮內窘迫髮生率為22.86％,低體重兒所佔比例為30.00％,與對照組相比,均顯著升高,差異具有統計學意義(P＜0.01).結論 妊娠期肝內膽汁淤積癥可以增加圍生期併髮癥的髮生率,嚴重影響胎兒的預後,加彊對妊娠期肝內膽汁淤積癥的鑑測具有重要臨床意義.
목적 탐토임신기간내담즙어적증대임신결국적영향.방법 70례학진위간내담즙어적증적임신기부녀설위연구조,선취동일시기70례건강임신부녀설위대조조.대량조임신기부녀적임신결국진행비교.결과 (1)연구조잉산부혈청담즙산、곡안산안기전이매、천동안산안기전이매수평분별위(65.61±13.5) μmol/L、(134.31±24.7) U/L、(97.35±21.54) U/L,균고우대조조적(3.34±0.41) μmol/L、(36.16±4.15) U/L、(23.34±4.45) U/L,차이구유통계학의의(P＜0.01)；(2)연구조잉산부임신기고혈압질병발병솔위21.42％,태막조파발생솔위17.14％,산후출혈발생솔위15.71％,현저고우대조조적7.14％、5.71％、4.29％,차이구유통계학의의(P＜0.05)；(3)연구조신생인질식발생솔위27.14％,양수오염발생솔위35.71％,궁내군박발생솔위22.86％,저체중인소점비례위30.00％,여대조조상비,균현저승고,차이구유통계학의의(P＜0.01).결론 임신기간내담즙어적증가이증가위생기병발증적발생솔,엄중영향태인적예후,가강대임신기간내담즙어적증적감측구유중요림상의의.
Objective To investigate the pregnancy outcome of gestational intrahepatic cholestasis.Methods 70 pregnant women with intrahepatic cholestasis were selected as the study group.70 healthy pregnant women during the same period were selected as the control group.The pregnancy outcomes of two groups were compaind.Results (1) The maternal serum levels of bile acid,alanine aminotransferase,aspartate aminotransferase in study group were (65.61 ± 13.5) μmol/L,(134.31 ± 24.7) U/L,(97.35 ± 21.54) U/L,which were higher than those of the control group (3.34 ± 0.41) μ mol/L,(36.16 ± 4.15) U/L,(23.34 ± 4.45) U/L,and the differences were statistically significant(P ＜0.01).(2) In study group,the incidence rate of maternal gestational hypertension was 21.42％,premature rupture of membranes was 17.14％,incidence rate of postpartum hemorrhage was 15.71％,which were significantly higher than 7.14％,5.71％,4.29％ in the control group,the differences were statistically significant(P ＜ 0.05).(3) In study group,the incidence rate of neonatal asphyxia was 27.14％,therate of amniotic fluid contamination was 35.71％,fetal distress was 22.86％ and 30.00％ of the childrenwith low birth weight,whichwere higher than those of the control group,the differences were statistically significant(P ＜0.01).Conclusion Pre gnancy intrahepatic cholestasis can increase the incidence rate of perinatal complications,has serious impact on the prognosis of the fetus,and to strengthen the monitoring of pregnancy intrahepatic cholestasis has important clinical significance.
