CAJ | 학술논문

机械应力在骨的生长重建过程中起着重要的作用。骨组织在外力作用下产生的应力，可通过多种信号途径调节成骨细胞和破骨细胞的分化，实现骨组织的代谢平衡。在口腔医学领域，成骨细胞是牙槽骨形成的主要细胞，成骨细胞对机械应力的早期反应主要依赖于细胞间通讯、缝隙连接、钙离子信号通道和流体切应力等实现。本文就机械应力作用下的成骨细胞，机械应力作用下的成骨细胞的早期反应调节等研究进展作一综述。
궤계응력재골적생장중건과정중기착중요적작용。골조직재외력작용하산생적응력，가통과다충신호도경조절성골세포화파골세포적분화，실현골조직적대사평형。재구강의학영역，성골세포시아조골형성적주요세포，성골세포대궤계응력적조기반응주요의뢰우세포간통신、봉극련접、개리자신호통도화류체절응력등실현。본문취궤계응력작용하적성골세포，궤계응력작용하적성골세포적조기반응조절등연구진전작일종술。
Mechanical stress plays an important role in the remodeling of bone. Stress can regulate the differen-tiation and function of osteoblasts and osteoclasts through a variety of signaling pathways, so as to achieve a bal-ance of bone metabolism. Osteoblasts are regarded as the main cells participating in the formation of alveolar bone in stomatology. Early responses of osteoblasts to mechanical stress mainly depend on: Cell-cell communication, gap junctions, calcium ion signal pathway and fluid shear stress, etc.. This article summarized the early responses of osteoblasts to mechanical loading.