CAJ | 학술논문

目的：探讨血清胱抑素C与妊娠期糖尿病（Gestational Diabetes Mellitus, GDM）早期肾损害的相关性，研究血清胱抑素C在妊娠期糖尿病早期肾损害诊断的价值。方法选取2010年8月~2013年1月于我院进行定期产检明确诊断为GDM并符合入选标准者91例为研究对象（GDM组），选取同期的90名正常妊娠孕妇为对照组，检测两组孕妇的血清胱抑素C、糖化血红蛋白、血尿素氮（BUN）和血肌酐（SCr）及尿微量白蛋白（mAlb），并进行统计分析。结果 GDM组血清胱抑素C、糖化血红蛋白及尿微量白蛋白均较对照组明显升高，两组比较有显著统计学差异（P=0.000，P=0.001，P=0.000）；但血尿素氮、血肌酐在两组比较差异无统计学意义（P>0.05）。GDM组中血清胱抑素C分别与糖化血红蛋白、尿微量白蛋白呈正相关（P=0.001，P=0.000），正常妊娠组中血清胱抑素C与各指标检测值无相关性（P>0.05）。结论血清胱抑素C水平的升高与妊娠期糖尿病早期肾损害的有密切相关，对早期肾损害的诊断及病情的评估有重要的作用。
목적：탐토혈청광억소C여임신기당뇨병（Gestational Diabetes Mellitus, GDM）조기신손해적상관성，연구혈청광억소C재임신기당뇨병조기신손해진단적개치。방법선취2010년8월~2013년1월우아원진행정기산검명학진단위GDM병부합입선표준자91례위연구대상（GDM조），선취동기적90명정상임신잉부위대조조，검측량조잉부적혈청광억소C、당화혈홍단백、혈뇨소담（BUN）화혈기항（SCr）급뇨미량백단백（mAlb），병진행통계분석。결과 GDM조혈청광억소C、당화혈홍단백급뇨미량백단백균교대조조명현승고，량조비교유현저통계학차이（P=0.000，P=0.001，P=0.000）；단혈뇨소담、혈기항재량조비교차이무통계학의의（P>0.05）。GDM조중혈청광억소C분별여당화혈홍단백、뇨미량백단백정정상관（P=0.001，P=0.000），정상임신조중혈청광억소C여각지표검측치무상관성（P>0.05）。결론혈청광억소C수평적승고여임신기당뇨병조기신손해적유밀절상관，대조기신손해적진단급병정적평고유중요적작용。
Objective To investigate the correlation of Serum Cystatin C(CysC) with early renal damage of Gestational Diabetes Mellitus (GDM), and to study the application value of CysC in early renal damage of GDM. Method 91 cases were selected as the research objects (GDM Group), who were checked regularly and diagnosed clearly as GDM from August 2010 to January 2013 in our hospital, 90 cases of normal pregnant woman were selected in the same period for control group. For all the pregnant women the microamount CysC, Glycosylated hemoglobin, blood urea nitrogen(BUN), creatinine (Scr) and urine microalbumn(mALB) were measured and statistically analyzed. Results The levels of CysC and Glycosylated hemoglobin and mALB in GDM group were significantly higher than those of control group(P=0.000, P=0.001, P=0.000), the levels of BUN and Scr had no significant difference between these two groups (P>0.05). CysC was correlated positively with Glycosylated hemoglobin and mALB seperately in the GDM group (P=0.001, P=0.000). But CysC had no correlation with those in control group (P>0.05). Conclusions The increase of CysC level is related closely to the early renal damage of GDM. CysC plays an important role to diagnose the early renal damage and evaluate the progression of GDM.