CAJ | 학술논문

目的：观察丁苯酞对急性脑梗塞大鼠海马中信号转导与转录活化因子5（Stat-5）表达的影响。方法将60健康雄性SD大鼠急性脑梗死患者随机分为治疗组（n=30）和对照组（n=30）。治疗组及对照组根据干预时间不同又随机分为2h组、12h组、24h组，用TTC染色和免疫组化染色观察大鼠脑梗死体积及海马区STAT-5蛋白的表达水平。结果治疗组的2h组及12h组的梗死体积明显小于模型对照组各对应时间点(P<0.05)，而24h组与模型对照组比较，梗死体积虽有所缩小但尚不具有明显差异；治疗组Stat-5的表达水平均较对照组明显降低。结论急性脑梗塞应用丁苯酞治疗可以减小脑梗死体积，降低海马区Stat-5阳性细胞数，疗效确切。
목적：관찰정분태대급성뇌경새대서해마중신호전도여전록활화인자5（Stat-5）표체적영향。방법장60건강웅성SD대서급성뇌경사환자수궤분위치료조（n=30）화대조조（n=30）。치료조급대조조근거간예시간불동우수궤분위2h조、12h조、24h조，용TTC염색화면역조화염색관찰대서뇌경사체적급해마구STAT-5단백적표체수평。결과치료조적2h조급12h조적경사체적명현소우모형대조조각대응시간점(P<0.05)，이24h조여모형대조조비교，경사체적수유소축소단상불구유명현차이；치료조Stat-5적표체수평균교대조조명현강저。결론급성뇌경새응용정분태치료가이감소뇌경사체적，강저해마구Stat-5양성세포수，료효학절。
Objective:To observe the effects of Butylphthalide on the expression of Stat-5 in the hippocampus of rats with acute cerebral infarction. Methods 60 healthy male SD rats with acute cerebral infarction were randomly divided into treatment group(N=30) and control group(N=30). Each group was divided into three groups according to the intervention time;2h,12h,24h group. TTC dying and immunohistochemistry dying were performed to assess infarct volume and the expressions of Stat-5 in hippocampus. Results compared with model control group ,the infarct volume in 2 h intervention group and 12 h intervention group obviously decreased(P<0.05).the infarct volume in 24 h intervention group slightly reduced. but no significance yet; The expressions Stat-5 at each time point in model intervention group were distinctly less than that in model control group. Conclusions Butylphthalide injection can reduce the expression of Stat-5 in rats of acute cerebral infarction,diminish infarct volume. and the therapeutic effect is effective.