CAJ | 학술논문

【目的】探讨妊娠相关血浆蛋白 A与缺血性脑血管疾病之间的相关性。【方法】选择短暂脑缺血发作（T IA ）48例及缺血性脑卒中患者120例，卒中患者根据梗死体积分为小梗死灶组58例、中梗死灶组32例、大梗死灶组30例。分别测定各组血清妊娠相关血浆蛋白A （PA PP-A ）及颈动脉内膜中层厚度（IM T ）等进行组间比较。【结果】梗死组中血清PA PP-A及IM T明显高于T IA组（ P＜0．05），同时PA PP-A浓度与脑梗死面积呈正相关（ r ＝0．345，P ＜0．05）。【结论】PAPP-A对评估不同程度缺血性脑卒中是一个有用的生物学指标。
【목적】탐토임신상관혈장단백 A여결혈성뇌혈관질병지간적상관성。【방법】선택단잠뇌결혈발작（T IA ）48례급결혈성뇌졸중환자120례，졸중환자근거경사체적분위소경사조조58례、중경사조조32례、대경사조조30례。분별측정각조혈청임신상관혈장단백A （PA PP-A ）급경동맥내막중층후도（IM T ）등진행조간비교。【결과】경사조중혈청PA PP-A급IM T명현고우T IA조（ P＜0．05），동시PA PP-A농도여뇌경사면적정정상관（ r ＝0．345，P ＜0．05）。【결론】PAPP-A대평고불동정도결혈성뇌졸중시일개유용적생물학지표。
[Objective] To explore the relationship between pregnancy-associated plasma protein A (PAPP-A) and ischemic cerebral disease .[Methods] A total of 48 patients with transient ischemic attack(TIA) and 120 patients with ischemic stroke were enrolled in the study .According to infarction size ,patients with ische-mic stroke were divided into small infarction lesion group( n=58) ,middle infarction lesion group( n=32) and large infarction lesion group( n=30) .Serum PAPP-A and intima-media thickness(IMT) in each group were measured and compared .[Results] Serum PAPP-A and IMT in infarction group were obviously higher than those in TIA group( P<0 .05) .Meanwhile ,PAPP-A level was positively correlated with infarction size ( r =0 .345 ,P <0 .05) .[Conclusion] PAPP-A may be an useful biomarker of ischemic stroke in different degrees .