CAJ | 학술논문

目的：探讨经皮自体骨髓干细胞移植治疗胫骨骨折骨不连的疗效。方法回顾2007年至2011年采用自体骨髓干细胞移植治疗胫骨骨折骨不连患者11例。抽取自身骨髓,送检、分离及培养扩增骨髓间充质干细胞( MSCs)后,在X线透视下用一枚骨穿针经皮刺入骨不连部位注射,术后加压包扎,随访复查X线片。结果11例全部获得随访,随访时间为4~27个月,平均13个月,X线片显示骨折愈合良好,未见不良事件的发生。结论经皮自体骨髓干细胞移植治疗胫骨骨折骨不连疗效满意,尤其是对于合并有严重皮肤软组织损伤瘢痕愈合者有临床应用价值。
목적：탐토경피자체골수간세포이식치료경골골절골불련적료효。방법회고2007년지2011년채용자체골수간세포이식치료경골골절골불련환자11례。추취자신골수,송검、분리급배양확증골수간충질간세포( MSCs)후,재X선투시하용일매골천침경피자입골불련부위주사,술후가압포찰,수방복사X선편。결과11례전부획득수방,수방시간위4~27개월,평균13개월,X선편현시골절유합량호,미견불량사건적발생。결론경피자체골수간세포이식치료경골골절골불련료효만의,우기시대우합병유엄중피부연조직손상반흔유합자유림상응용개치。
Objective To investigate the effect of the percutaneous autologous bone marrow stem cell transplantation for the treatment of nonunion of tibial fracture. Methods From 2007 to 2011,the data of 11 patients with tibial nonunion who received autologous bone marrow stem cell transplantation was analyzed retrospectively. Taking bone marrow,examine,isolation,cultivation and expansion marrow mesenchymal stem cells( MSCs) ,and then marrow needle was inserted into the site of the nonunion under the X-ray,the MSCs were injected into the site of nonunion. Compression bandage was applied after operation. X-rays following-up were reviewed. Results All 11 patients were followed up from 4~27 months,with average of 13 months,X-ray showed:fracture healed well,no adverse events happen. Conclusion Satisfactory out-come can be obtained by percutaneous autologous bone marrow stem cell transplantation in treatment of tibial nonunion. Clinical application value is high,especially to patients who had suffered from severe skin and soft tissue injury with keloids healed.