CAJ | 학술논문

目的：研究中枢神经细胞瘤( CNC)的MRI影像学特点及其临床意义。方法回顾性分析2010年1月至2012年12月确诊并行手术治疗的CNC患者9例,患者均在术前进行MRI,术后进行组织病理学检查。结果9例CNC均于左侧脑室内,并与Monro孔紧密相连,其中4例位于左侧脑室中部脑室前的2/3,3例位于透明隔并向双侧脑室内生长,2例浸润于透明隔且和基底边侧粘连。 CNC中,MRI 信号不均,实性部分T1WI呈等或稍低信号,周围可见多发囊变及等信号条索样结构与脑室壁及透明隔粘连。增强扫描,实性部分明显不均匀性强化4例,中度和轻度不均匀性强化分别3例和2例。 HE染色见大小均匀一致、圆形或卵圆形瘤细胞；免疫组化染色后突触素阳性表达6例,胶质纤维酸性蛋白阳性表达3例。术后3例失去随访,随访的6例中,生存3年2例,生存2年4例。结论青年患者MRI显示位于侧脑室前中部及Monro孔附近占位性病变,则提示为CNC；CNC免疫组化染色后大多数突触素阳性表达。
목적：연구중추신경세포류( CNC)적MRI영상학특점급기림상의의。방법회고성분석2010년1월지2012년12월학진병행수술치료적CNC환자9례,환자균재술전진행MRI,술후진행조직병이학검사。결과9례CNC균우좌측뇌실내,병여Monro공긴밀상련,기중4례위우좌측뇌실중부뇌실전적2/3,3례위우투명격병향쌍측뇌실내생장,2례침윤우투명격차화기저변측점련。 CNC중,MRI 신호불균,실성부분T1WI정등혹초저신호,주위가견다발낭변급등신호조색양결구여뇌실벽급투명격점련。증강소묘,실성부분명현불균균성강화4례,중도화경도불균균성강화분별3례화2례。 HE염색견대소균균일치、원형혹란원형류세포；면역조화염색후돌촉소양성표체6례,효질섬유산성단백양성표체3례。술후3례실거수방,수방적6례중,생존3년2례,생존2년4례。결론청년환자MRI현시위우측뇌실전중부급Monro공부근점위성병변,칙제시위CNC；CNC면역조화염색후대다수돌촉소양성표체。
Objective To study the clinical significance of MR imagings features in the diagnosis on central neurocytoma ( CNC ) . Methods From January 2010 to December 2012,9 patients with CNC were analyzed and examined by MRI before surgery,then received postoperative pathology examination. Results CNC were in the left lateral ventricle of 9 patients, closely linked with the Monro hole, of which 4 cases were in the first 2/3 of central ventricle of the left lateral ventricle,3 cases in the septum pellucidum and growth to bilateral ventricles,2 cases of infiltrating in the septum pellucidum and base side adhesion. For CNC,MRI signal was not uniform,solid part T1WI showed equal or slightly low signal,multiple cysts and signal cord like structure with the ventricular wall and septum pellucidum adhesion. By contrast-enhanced CT scan,there were the solid part heterogeneous obvious enhancement in 4 cases,moderate and slight uneven enhancement in 3 cases and 2 cases respectively. Uniform size,round or oval cells were showed by HE staining,and the synaptophysin was positive in 6 ca-ses by immunohistochemical staining,positive expression of glial fibrillary acidic protein in 3 cases. After operation,3 patients were lost to fol-low up,for 6 cases were followed up,survival of 2 cases in 3 years,4 cases in 2 years. Conclusion The results suggest that MRI display is located near the lateral ventricle central Monro hole before and lesions suggestive of CNC in young patients. For most CNC,synaptophysin has positive expression by immunohistochemical staining.