CAJ | 학술논문

采用紫外-可见分光光度法测定了柿叶总黄酮缓释微丸在人工胃液和磷酸盐缓冲液（pH＝6．8）中的累积释药率，并分别对其释药模型进行拟合．结果显示缓释微丸在磷酸盐缓冲液中12 h的累积释药率为83．22％，释药模型符合 Higuchi方程；在人工胃液中12 h的累积释药率为55．42％，释药模型为 Higuchi方程．相较于人工胃液，柿叶总黄酮缓释微丸在磷酸盐缓冲液中具有良好的释药性能．
채용자외-가견분광광도법측정료시협총황동완석미환재인공위액화린산염완충액（pH＝6．8）중적루적석약솔，병분별대기석약모형진행의합．결과현시완석미환재린산염완충액중12 h적루적석약솔위83．22％，석약모형부합 Higuchi방정；재인공위액중12 h적루적석약솔위55．42％，석약모형위 Higuchi방정．상교우인공위액，시협총황동완석미환재린산염완충액중구유량호적석약성능．
Applying ultraviolet-visible spectrophotometry in artificial gastric juice and phos-phate buffer solution (pH=6 .8) to investigate the cumulative drug release rate of total fla-vonoids suatained-release micropills from persimmon leaves ,and the drug release models were also tested respectively .Results have shown that the cumulative drug release rate in phosphate buffer solution reached to 83 .22% for 12 hours ,and its drug release model was consistent with Higuchi equation .However ,in artificial gastric juice ,the cumulative drug release rate only reached to 55 .42% during the same period ,and its drug release model was also in accordance with Higuchi equation .Conclusions have been made that compared with artificial gastric juice ,sustained-release micropills in phosphate buffer solution showed satis-factory drug release characteristics .