CAJ | 학술논문

目的：研究多沙普仑和哌替啶对于全麻后寒战患者的治疗效果及对苏醒质量的影响。方法将全麻苏醒期进入术后恢复室后发生寒战的51例全麻病人随机分三组治疗：多沙普伦针1.0 mg/kg （多沙普仑组）、哌替啶针0.5 mg/kg（哌替啶组）及0.9％氯化钠注射液（对照组），比较三组患者的降低寒战分级、寒战终止率，并观察对镇静、镇痛的影响及不良反应发生率。结果治疗1 min、2.5 min和5 min后多沙普仑组和哌替啶组寒战等级相比对照组均有明显降低，差异均有统计学意义（H分别=18.97、24.96、30.85，P均＜0.05）。治疗1 min后，多沙普仑组和哌替啶组寒战终止率明显高于对照组，差异均有统计学意义（χ2=5.04、11.10，P＜0.05）。而哌替啶组24 h内恶心、呕吐的发生率明显高于多沙普仑组和对照组，经Fisher精确检验，差异均有统计学意义（P均＜0.05）。三组之间术后恢复室停留时间比较，差异无统计学意义（F=8.63，P＞0.05）。结论全麻术后寒战患者使用多沙普仑和哌替啶都有明显中止寒战效果，哌替啶会增加术后恶心呕吐的发生。对已经苏醒的患者，两药对全麻的恢复无明显影响。
목적：연구다사보륜화고체정대우전마후한전환자적치료효과급대소성질량적영향。방법장전마소성기진입술후회복실후발생한전적51례전마병인수궤분삼조치료：다사보륜침1.0 mg/kg （다사보륜조）、고체정침0.5 mg/kg（고체정조）급0.9％록화납주사액（대조조），비교삼조환자적강저한전분급、한전종지솔，병관찰대진정、진통적영향급불량반응발생솔。결과치료1 min、2.5 min화5 min후다사보륜조화고체정조한전등급상비대조조균유명현강저，차이균유통계학의의（H분별=18.97、24.96、30.85，P균＜0.05）。치료1 min후，다사보륜조화고체정조한전종지솔명현고우대조조，차이균유통계학의의（χ2=5.04、11.10，P＜0.05）。이고체정조24 h내악심、구토적발생솔명현고우다사보륜조화대조조，경Fisher정학검험，차이균유통계학의의（P균＜0.05）。삼조지간술후회복실정류시간비교，차이무통계학의의（F=8.63，P＞0.05）。결론전마술후한전환자사용다사보륜화고체정도유명현중지한전효과，고체정회증가술후악심구토적발생。대이경소성적환자，량약대전마적회복무명현영향。
Objective To compare the effect of doxapram and pethidine on postoperative shiver in general anesthesia re-covery period. Methods Fifty-one patients who shivered during recovery from general anesthesia were randomly divided into three groups: doxapram group that received doxapram 1.0mg/kg, pethidine group that received pethidine 0.5 mg/kg and control group that received normal saline. Shiver grade and the rate of shiver stopped were compared. The effect of two drugs on sedation and analgesia and adverse effect incidence were observed. Results At 1, 2.5 and 5 minutes after treat-ment, both doxapram and pethidine groups were significantly effective in reducing postoperative shivering grade comparing with control group (H=18.97,24.96,30.85,P<0.05). At 1 minute after treatment, the rate of shiver stopped of both doxapram and pethidine groups were significantly higher than control group (χ2=5.04,11.10,P<0.05). But pethidine group had significantly higher incidence of postoperative nausea and vomiting comparing with doxapram or saline at 24 hours(P<0.05). There were no statistical difference of stay time in recovery room among the three groups (F=8.63,P>0.05). Con-clusion Both doxapram and pethidine were effective for postoperative shiver while pethidine had higher incidence of post-operative nausea and vomiting. The doxapram and pethidine were unaffected general anesthesia recovery when as to already awake patients.