CAJ | 학술논문

目的：观察不同剂量右美托咪定用于治疗全麻术后寒战的临床效果、安全性和不良反应。方法：ASAⅠ~Ⅱ级全身麻醉下行腹部手术后在恢复室出现4级寒战的患者60例，随机分为A、B、C 3组(每组20例)：静注右美托咪定A组0.25μg/kg、B组0.5μg/kg、C组1μg/kg，3组患者均于10 min内输完。观察各组患者的寒战转归情况；各组患者用药前后心率、血压的变化；观察用药后不良反应，包括恶心、呕吐、口干、呼吸抑制(呼吸<10 min-1或血氧饱和度<90%)、心动过缓(心率<50 min-1)。结果：A组治疗4级寒战显效率显著低于B组和C组(P<0.05)。各组患者寒战发生后血压、心率均不同程度增高，各组用药后血压、心率显著下降(P<0.05)。结论：静脉泵注右美托咪定0.5μg/kg治疗全麻术后寒战是安全可靠的。
목적：관찰불동제량우미탁미정용우치료전마술후한전적림상효과、안전성화불량반응。방법：ASAⅠ~Ⅱ급전신마취하행복부수술후재회복실출현4급한전적환자60례，수궤분위A、B、C 3조(매조20례)：정주우미탁미정A조0.25μg/kg、B조0.5μg/kg、C조1μg/kg，3조환자균우10 min내수완。관찰각조환자적한전전귀정황；각조환자용약전후심솔、혈압적변화；관찰용약후불량반응，포괄악심、구토、구간、호흡억제(호흡<10 min-1혹혈양포화도<90%)、심동과완(심솔<50 min-1)。결과：A조치료4급한전현효솔현저저우B조화C조(P<0.05)。각조환자한전발생후혈압、심솔균불동정도증고，각조용약후혈압、심솔현저하강(P<0.05)。결론：정맥빙주우미탁미정0.5μg/kg치료전마술후한전시안전가고적。
Objectiv e: To observe the effects and safety and adverse reactions of different doses of dexmedetomidine being used for the treatment of postoperative anesthesia shivering. Methods: Sixty general anesthesia for abdominal surgery patients after four shivering in the recovery room, with ASA grades Ⅰand Ⅱ, were randomly divided into three groups(twenty cases each group): intravenous dexmedetomidine group A given 0.25 μg/kg, group B 0.5 μg/kg, group C 1 μg/kg, three groups patients were injected within 10 min. To observe the chills outcomes and heart rate and the changes in blood pressure of pa-tients in each group before and after treatment;to observe the adverse reactions after treatment , including nausea , vomiting , dry mouth, respiratory depression (RR<10 min-1 or SpO2<90%), bradycardia (HR<50 min-1). Results: The four chills sig-nificant efficiency was significantly lower in group A than those in group B and group C (P<0.05). The occurrence of chills and the blood pressure and heart rate at patients in each group were increased to various , each group after treatment of blood pressure, heart rate decreased significantly after treatment (P<0.05). Conclusion: Intravenous 0.5 μg/kg dexmedetomi-dine infusion treating shivering after general anesthesia is safe and reliable.