CAJ | 학술논문

【目的】探讨血清脂蛋白a（LPa）、脑利钠肽（pro-BNP）、肌钙蛋白I（TnI）及总胆红素（TBIL）与慢性心力衰竭患者预后的关系。【方法】选取2012年1月至2013年4月于本院进行诊治的94例慢性心衰患者设为观察组，并以94名体检的健康人员设为对照组，将两组患者的血清LPa、pro-BNP、TnI及 TBIL水平进行比较，同时对观察组中不同纽约心功能分级（NYHA分级）患者的检测水平进行比较，分析各指标与心衰的关系。【结果】观察组血清LPa、pro-BNP、TnI及TBIL水平均高于对照组（ P ＜0．05）；观察组中NYHA分级高者各指标水平高于分级低者（ P＜0．05）；经Logistic回归分析显示血清LPa、pro-BNP、TnI及TBIL均与疾病有密切的关系（ P ＜0．05）。【结论】血清LPa、pro-BNP、TnI及 TBIL在慢性心衰患者中较对照组明显升高，且与NYHA分级关系密切，可在一定程度上反映疾病的严重程度，据此认为可作为判断疾病预后的指标，具有临床应用价值。
【목적】탐토혈청지단백a（LPa）、뇌리납태（pro-BNP）、기개단백I（TnI）급총담홍소（TBIL）여만성심력쇠갈환자예후적관계。【방법】선취2012년1월지2013년4월우본원진행진치적94례만성심쇠환자설위관찰조，병이94명체검적건강인원설위대조조，장량조환자적혈청LPa、pro-BNP、TnI급 TBIL수평진행비교，동시대관찰조중불동뉴약심공능분급（NYHA분급）환자적검측수평진행비교，분석각지표여심쇠적관계。【결과】관찰조혈청LPa、pro-BNP、TnI급TBIL수평균고우대조조（ P ＜0．05）；관찰조중NYHA분급고자각지표수평고우분급저자（ P＜0．05）；경Logistic회귀분석현시혈청LPa、pro-BNP、TnI급TBIL균여질병유밀절적관계（ P ＜0．05）。【결론】혈청LPa、pro-BNP、TnI급 TBIL재만성심쇠환자중교대조조명현승고，차여NYHA분급관계밀절，가재일정정도상반영질병적엄중정도，거차인위가작위판단질병예후적지표，구유림상응용개치。
[Objective]To explore the correlation of serum lipoprotein (a) ,pro-BNP ,troponin I and total bilirubin with the prognosis of patients with chronic heart failure .[Methods] A total of 94 patients diagnosed as chronic heart failure in our hospital from Jan .2012 to April 2013 were enrolled as observation group ,and 94 healthy people were included as control group .Serum levels of lipoprotein(a) ,pro-BNP ,troponin I and to-tal bilirubin of two groups were measured and compared .The NYHA classification was applied to evaluate heart function of patients with chronic heart failure ,and the correlation between the above four serum biomar-kers and heart failure was analyzed .[Results]Serum levels of lipoprotein (a) ,pro-BNP ,troponin I and total bilirubin in observation group were higher than those in control group ( P <0 .05) .In observation group ,the above indexes of patients with high grade NYHA were higher than those of patients with low grade NYHA ( P<0 .05) .Logistic regression analysis showed that serum levels of lipoprotein (a) ,pro-BNP ,troponin I and to-tal bilirubin were closely related with the disease ( P <0 .05) .[Conclusion]Compared with control group ,ser-um lipoprotein(a) ,pro-BNP ,troponin I and total bilirubin in patients with chronic heart failure are obviously increased and closely correlated with NYHA class .These biomarkers can reflect the severity of the disease , which suggests that they can be used as the indicators for assessing the prognosis of the disease ,and have clin-ical application value .