CAJ | 학술논문

目的：探讨阿立哌唑治疗儿童青少年抽动障碍患者的临床疗效和安全性。方法对25例应用其他药物治疗效果不佳或耐受性较差的儿童青少年抽动障碍患者换用阿立哌唑治疗，观察10周。于治疗前后采用耶鲁抽动量表评定临床疗效，副反应量表评定不良反应。结果本组患者治疗10周末耶鲁抽动量表总分及运动抽动、发声抽动、功能损害评分均较基线显著下降（P＜0．01）；不良反应较轻微，主要表现为失眠、激越、头痛等。结论阿立哌唑治疗儿童青少年抽动障碍疗效显著，安全性高，依从性好。
목적：탐토아립고서치료인동청소년추동장애환자적림상료효화안전성。방법대25례응용기타약물치료효과불가혹내수성교차적인동청소년추동장애환자환용아립고서치료，관찰10주。우치료전후채용야로추동량표평정림상료효，부반응량표평정불량반응。결과본조환자치료10주말야로추동량표총분급운동추동、발성추동、공능손해평분균교기선현저하강（P＜0．01）；불량반응교경미，주요표현위실면、격월、두통등。결론아립고서치료인동청소년추동장애료효현저，안전성고，의종성호。
Objective To explore the efficacy and safety of aripiprazole in child and adolescent tic disorder . Methods Twenty-five tic disorder children and adolescents who had poor treatment effectiveness or toler-ance with other drugs were treated with aripiprazole for 10 weeks .Efficacies with assessed with the Yale Global Tic Severity Scale (YGTSS) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results At the end of the 10th week total ,motor tic ,vocal tic and functional lesion score of the YGTSS lowered more significantly compared with pretreatment (P<0 .01);adverse reactions were mild and mainly insomnia ,agitation ,headache and so on .Conclusion Aripiprazole has an evident effect ,higher safety and better compliance in child and adolescent tic disorder .