CAJ | 학술논문

目的：探讨奥氮平联合丙戊酸钠治疗双相Ⅰ型障碍急性躁狂发作的临床疗效和安全性。方法将60例双相Ⅰ型障碍急性躁狂发作患者随机分为两组，两组均口服丙戊酸钠治疗，研究组联合奥氮平治疗，观察6周。于治疗前后采用Bech-Rafaelsen躁狂量表评定临床疗效，副反应量表评定不良反应。结果治疗6周末研究组痊愈率69．0％，对照组为17．9％，研究组痊愈率显著高于对照组（χ2＝15．11，P＜0．01）；治疗过程中两组均未出现严重不良反应。结论丙戊酸钠联合奥氮平治疗双相Ⅰ型障碍急性躁狂发作较单用丙戊酸钠起效更快，效果更显著，且安全性高。
목적：탐토오담평연합병무산납치료쌍상Ⅰ형장애급성조광발작적림상료효화안전성。방법장60례쌍상Ⅰ형장애급성조광발작환자수궤분위량조，량조균구복병무산납치료，연구조연합오담평치료，관찰6주。우치료전후채용Bech-Rafaelsen조광량표평정림상료효，부반응량표평정불량반응。결과치료6주말연구조전유솔69．0％，대조조위17．9％，연구조전유솔현저고우대조조（χ2＝15．11，P＜0．01）；치료과정중량조균미출현엄중불량반응。결론병무산납연합오담평치료쌍상Ⅰ형장애급성조광발작교단용병무산납기효경쾌，효과경현저，차안전성고。
Objective To explore the efficacy and safety of sodium valproate plus olanzapine in the treat-ment of acute manic episode of bipolar I disorder .Methods Sixty patients with acute manic episode of bi-polar I disorder were randomly divided into two groups ,both groups took orally sodium valproate ,and re-search group was plus olanzapine for 6 weeks .Efficacies were assessed with the Bech-Rafaelsen Mania Rat-ing Scale (BRMS) before and after treatment and adverse reactions with the Treatment Emergent Symp-tom Scale (TESS) .Results At the end of the 6th week cure rate was significantly higher in research than in control group (69 .0% vs .17 .9% ,χ2 =15 .11 , P<0 .01);both groups had no severe adverse reactions during treatment .Conclusion Sodium valproate plus olanzapine takes effects more rapidly and has a more evident effect and higher safety in the treatment of acute manic episode of bipolar I disorder .