CAJ | 학술논문

急性肾损伤是一种ICU患者中常见的疾病，致死率较高，当合并肺损伤时，致死率显著提高，可达到80%。急性肾损伤可导致全身体液灌注量增加，血浆渗透压升高进而引起肺水肿和急性呼吸衰竭。同时，炎症反应，氧化应激，细胞凋亡和可溶性调节因子代谢异常等也可能参与急性肾损伤诱导的肺损伤。对急性肾损伤诱导肺损伤的临床认识和可能发病机制的研究，将有助于临床疾病的治疗和死亡率的降低，同时也将有助于对其它肾脏疾病发病机制的认识。
급성신손상시일충ICU환자중상견적질병，치사솔교고，당합병폐손상시，치사솔현저제고，가체도80%。급성신손상가도치전신체액관주량증가，혈장삼투압승고진이인기폐수종화급성호흡쇠갈。동시，염증반응，양화응격，세포조망화가용성조절인자대사이상등야가능삼여급성신손상유도적폐손상。대급성신손상유도폐손상적림상인식화가능발병궤제적연구，장유조우림상질병적치료화사망솔적강저，동시야장유조우대기타신장질병발병궤제적인식。
Acute kidney injury(AKI)is a common disease with high mortality rate in the department of ICU. When AKI combined with acute lung injury(ALI), the mortality rate may be higher and reach 80%. Acute kidney injury can lead to increased systemic perfusion fluids and elevated plasma osmolality, and thus cause pulmonary edema and acute respiratory failure. It was helpful for treatment and lower mortality rate if we could know more about clinical features of AKI-induced AIL and its pathogenesis.